Potosí or Potosi may refer to:

• Bolivia
  • Potosí, a city, an important mining spot during the Spanish colonial rule
    • Potosí, a German Flying P-Liner sailing ship named after this place
  • Potosí Department, a department
  • Huayna Potosí, a mountain
• Colombia
  • Potosí, Nariño a town and municipality
• Jamaica
  • Potosi, Trelawny, Jamaica
• Mexico
  • San Luis Potosí, San Luis Potosí, a city
  • San Luis Potosí, a state
  • Cerro Potosí, a mountain
• Nicaragua
  • Potosí, Rivas, a municipality
• United States
  • Potosi, Missouri
  • Potosi, Texas
  • Potosi, Wisconsin
  • Potosi (town), Wisconsin
  • Potosi Mining District‎, Nevada

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