Phenprocoumon Information & Phenprocoumon Links at HealthHaven.com

Phenprocoumon
Systematic (IUPAC) name

(RS)-4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
Identifiers
CAS number	435-97-2
ATC code	B01AA04
PubChem	9908
DrugBank	APRD00228
Chemical data
Formula	C₁₈H₁₆O₃
Mol. mass	280.318 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	99%
Metabolism	hepatic to inactive metabolites
Half life	5 to 6 days
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is an anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism).

[edit] External links

DDB 29943

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban

ADP receptor/P2Y₁₂ inhibitors	(Thienopyridines) Clopidogrel • Ticlopidine • Prasugrel

Prostaglandin analogue (PGI2)	Beraprost • Prostacyclin • Iloprost • Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin # • Aloxiprin • Carbasalate calcium

Other	Ditazole • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal

Anticoagulants

Vitamin K antagonists
(inhibit II, VII, IX, X)

coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol (Dicumarol) • Ethyl biscoumacetate • Phenprocoumon • Warfarin

1,3-Indandiones: Clorindione • Diphenadione • Phenindione

other: Tioclomarol

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	low molecular weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin) oligosaccharides (Fondaparinux, Idraparinux) heparinoid (Danaparoid, Sulodexide, Dermatan sulfate)

Direct Xa inhibitors	xabans (Apixaban, Otamixaban, Rivaroxaban)