In Greek mythology, Pergamus was the son of the warrior Neoptolemus and Andromache. In the Bible, Pergamus was quoted as an Asian kingdom where the unknown being from the Book of Revelation sends a message to the seven churches of Asia. Revelations 2:12 (KJV) states, "And to the angel of the church of Pergamus write: These things, saith he, that hath the sharp two edged sword:" This Biblical city is usually called Pergamum.

Pergamus (or Pergamos) is also the name of the citadel of Troy in Homer's Iliad.

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