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Perfluorinated compounds (PFCs) refer to a class of organofluorine compounds that have all hydrogens replaced with fluorine on a carbon chain—but also contain at least one different atom or functional group. Thus, they have properties similar to fluorocarbons as they are fluorocarbon derivatives. They have unique properties to make materials stain, oil, and water resistant, and are widely used in diverse applications. PFCs persist in the environment as persistent organic pollutants, but unlike PCBs, they are not known to degrade by any natural processes due to the strength of the carbon–fluorine bond.[1]

There are many PFCs, but the two most studied[2] compounds are:

Other PFCs include:

Polyfluorinated compounds, such as fluorotelomers, can serve as precursors that degrade to form perfluorinated carboxylic acids, such as PFOA and PFNA.

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