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Percodan is a potent compound painkiller used to treat moderately severe to severe acute (short-term) pain. Percodan contains aspirin and oxycodone, a potent opioid agonist. Percodan was first marketed by DuPont Pharmaceuticals and prescribed in the United States in 1950. At one time one of the most widely prescribed painkillers ever in the history of the world, Percodan has largely been replaced by alternative oxycodone compounds containing acetaminophen (Tylenol) instead of aspirin, such as Percocet.

Contents 1 Pharmacology 2 Reformulation 3 Miscellaneous 4 External links

[edit] Pharmacology

Each Percodan tablet contains the following active ingredients:

• 4.8355 mg of oxycodone hydrochloride*
• 325 mg of aspirin

Each tablet also contains the following inactive ingredients:

• FD&C Yellow 10
• FD&C Yellow 6
• microcrystalline cellulose
• starch.

The oxycodone component in Percodan is technically 14-hydroxy-7,8-dihydrocodein-6-one, a white odorless, crystalline powder which is synthesized from the opium alkaloid thebaine. Thebaine by itself has no therapeutic value. Oxycodone is metabolized into oxymorphone. Unlike morphine and like codeine, oxycodone has a good oral potency. Prior to the introduction of acetaminophen (paracetamol), Percodan was the mainstay in post-operative oral pain treatment due to the potency and long half-life of oxycodone. Percodan originally contained a small amount of caffeine.

The usual dose is one tablet every six hours as needed for pain. The maximum daily dose should not exceed 42 tablets.

[edit] Reformulation

Percodan was reformulated in 2005; prior to 2005, Percodan contained two oxycodone salts -- 4.50 mg of oxycodone hydrochloride and 0.38 mg of oxycodone terephthalate. Since the latter salt is unusual in the pharmacopeia, the manufacturer increased the amount of oxycodone hydrochloride to 4.8355 and discontinued the oxycodone terephthalate.

[edit] Miscellaneous

Percodan is also sold under the brand name Endodan. All products containing oxycodone (including Percodan, Percocet, OxyContin) have the potential to be habit-forming. Oxycodone can produce drug dependence of the morphine type and, therefore, has the potential for being abused.

As of 2008, Percodan and Percocet are manufactured by Endo Pharmaceuticals.

[edit] External links

• Percodan Prescribing Information from Endo Pharmaceuticals.
• Search "Percodan" in FDA Archives; shows approval in 1950.