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Percocet
Combination of
Oxycodone	Opioid Analgesic
Acetaminophen	Anilide Analgesic
Identifiers
CAS number	?
ATC code	?
PubChem	?
Therapeutic considerations
Licence data	US FDA:link
Pregnancy cat.	?
Legal status	Schedule II(US)
Routes	Oral

Percocet is a trade name of Endo Pharmaceuticals for a narcotic pain killer used to treat moderate to severe acute (short-term) pain. The active ingredients of Percocet are oxycodone and acetaminophen.^[1]

[edit] History

The U.S. Food and Drug Administration first approved Percocet in 1976, under application ANDA 085106.^[2]

[edit] Pharmacology

Endo Pharmaceuticals currently manufactures Percocet, as well as Percodan which contains oxycodone and aspirin.^[3] Percocet tablets are available in six combinations of oxycodone hydrochloride and acetaminophen, with different appearances and maximum daily doses:^[3]

2.5 mg oxycodone HCl & 325 mg acetaminophen: pink oval tablet, maximum daily dose 12 tablets
5 mg oxycodone HCl & 325 mg acetaminophen: blue round tablet, maximum daily dose 12 tablets
7.5 mg oxycodone HCl & 325 mg acetaminophen: peach oval tablet, maximum daily dose 8 tablets
7.5 mg oxycodone HCl & 500 mg acetaminophen: peach capsule-shaped tablet, maximum daily dose 8 tablets
10 mg oxycodone HCl & 325 mg acetaminophen: yellow capsule-shaped tablet, maximum daily dose 6 tablets
10 mg oxycodone HCl & 650 mg acetaminophen: yellow oval tablet, maximum daily dose 6 tablets
10 mg oxycodone HCI &1000 mg acetaminophen: blue oval tablet, maximum daily dose 4 tablets

For the 2.5 mg oxycodone HCl tablet, the usual dose is 1-2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.^[3]

Watson Laboratories manufactures generic versions of five of the six types of Percocet tablets (with 5, 7.5, and 10 mg oxycodone HCl).^[4]

[edit] Abuse

Because it contains oxycodone, Percocet is a Schedule II drug under the Controlled Substances Act of the U.S.^[5]

[edit] Paracetamol/Acetaminophen Deaths

On June 30, 2009, an FDA advisory panel recommended that Percocet and another painkiller, Vicodin be removed from the market because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year.^[6] The problem is with paracetamol overdose and liver damage.

Well-known people who have abused Percocet include:

Model Niki Taylor began abusing Percocet in the late 1990s after the death of her sister and the "breakup of her marriage."^[7]

[edit] In popular culture

The title character on the show Nurse Jackie uses Percocet, ostensibly to deal with a bad back. It is implied that she is abusing it to cope with the stresses of her job and family life.
In the movie Pineapple Express, the cannabis dealer Saul Silver is asked if he has any Percocet.
In the movie Dogma (film), after being saved by Jay and Silent Bob from 3 Satanic teenagers Main Character Bethany (Linda Florentino) says: "I had a really weird night last night and tonight’s not shaping up to be any better, I think I should go home, take some percocets and lay down."
In the movie Jay and Silent Bob Strike Back. While stealing a monkey from a testing lab, Jay comes across a Tranquilizer gun and says; "Check this shit out Lunch Box (Silent Bob), animal tranquilizer, this shit fucks you up like Percocet."
In the movie Legally Blonde, one of Elle's sorority sisters suggests after her breakup with Warner, "can't you just take a Percocet?" to which another sister replies, "no honey, it's not like that."
In the movie the Savages, the character Wendy takes her father's girlfriends Percocet tablets, and is then shown in a dreamy haze being driven through the streets of Sun City, Arizona.

[edit] References

^ http://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf
^ "Drugs@FDA. FDA approved drug products (searchable database)". U.S. Food and Drug Administration, Center for Drug Evaluation and Research. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Retrieved 2009-03-30.
^ ^a ^b ^c "Percocet oxycodone and acetaminophen tablets USP". Endo Pharmaceuticals. 2006 November. http://www.endo.com/pdf/products/Percocet_pack_insert_4.pdf. Retrieved 2009-03-30.
^ "Oxycodone and acetaminophen tablets USP". Watson Laboratories, Inc. 2008 May. http://pi.watson.com/data_stream.asp?product_group=1293&p=pi&language=E. Retrieved 2009-03-30.
^ "Controlled substances in alphabetical order". U.S. Drug Enforcement Administration. http://www.deadiversion.usdoj.gov/schedules/alpha/alphabetical.htm. Retrieved 2009-03-30.
^ http://www.nytimes.com/2009/07/01/health/01fda.html?em
^ Dennis, Alicia (2009-01-19). "Model Niki Taylor 'I never thought i'd get pregnant again'". People Weekly. http://www.people.com/people/archive/article/0,,20252118,00.html. Retrieved 2009-03-30.

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

[0] ttp://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf

[1] "Drugs@FDA. FDA approved drug products (searchable database)". U.S. Food and Drug Administration, Center for Drug Evaluation and Research. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Retrieved 2009-03-30.

[insert-2] "Percocet oxycodone and acetaminophen tablets USP". Endo Pharmaceuticals. 2006 November. http://www.endo.com/pdf/products/Percocet_pack_insert_4.pdf. Retrieved 2009-03-30.

[3] "Oxycodone and acetaminophen tablets USP". Watson Laboratories, Inc. 2008 May. http://pi.watson.com/data_stream.asp?product_group=1293&p=pi&language=E. Retrieved 2009-03-30.

[4] "Controlled substances in alphabetical order". U.S. Drug Enforcement Administration. http://www.deadiversion.usdoj.gov/schedules/alpha/alphabetical.htm. Retrieved 2009-03-30.

[5] ttp://www.nytimes.com/2009/07/01/health/01fda.html?em

[6] Dennis, Alicia (2009-01-19). "Model Niki Taylor 'I never thought i'd get pregnant again'". People Weekly. http://www.people.com/people/archive/article/0,,20252118,00.html. Retrieved 2009-03-30.

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