Pepo can mean:a small seed inside of a fruit

• Pepo (film), a 1935 Armenian film made by Hamo Beknazarian
• Epigynous berry, an accessory fruit found in certain plant species
• Pepo (jurist), an 11th century law teacher at the University of Bologna
• René Ríos Boettiger, a cartoonist, who used Pepo as a pseudonym.

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