Penam Information & Penam Links at HealthHaven.com

Penams are a subclass of the broader β-lactam family of antibiotics and related compounds. Penams contain a β-lactam ring fused to a 5-membered ring, where one of the atoms in the ring is a sulfur and the ring is fully saturated. Penicillin is a member of this family of compounds.

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Antibacterials: cell envelope antibiotics (J01C-J01D)

Internal to membrane/
(inhibit peptidoglycan subunit
synthesis and transport)

NAM synthesis inhibition (Fosfomycin) · DADAL/AR inhibitors (Cycloserine) · bactoprenol inhibitors (Bacitracin)

Glycopeptide/
(inhibit PG chain elongation)

Vancomycin^# (Oritavancin, Telavancin) · Teicoplanin (Dalbavancin) · Ramoplanin

β-lactams/
(inhibit cross-links
with PBP)

Penicillins/
(penams)

Penems

Faropenem

Carbapenems

Biapenem · Doripenem · Ertapenem · Imipenem · Meropenem · Panipenem

Cephalosporins/
(cephems)

1st (P Ec K)	Cefazolin^# · Cefacetrile · Cefadroxil · Cefalexin · Cefaloglycin · Cefalonium · Cefaloridine · Cefalotin · Cefapirin · Cefatrizine · Cefazedone · Cefazaflur · Cefradine · Cefroxadine · Ceftezole

2nd (H E N)	Cefaclor · Cefamandole · Cefminox · Cefonicid · Ceforanide · Cefotiam · Cefprozil · Cefbuperazone · Cefuroxime · Cefuzonam · cephamycin (Cefoxitin, Cefotetan, Cefmetazole) · carbacephem (Loracarbef)

3rd	Cefixime^# · Ceftazidime^# · Ceftriaxone^# · Cefcapene · Cefdaloxime · Cefdinir · Cefditoren · Cefetamet · Cefmenoxime · Cefodizime · Cefoperazone · Cefotaxime · Cefpimizole · Cefpiramide · Cefpodoxime · Cefsulodin · Cefteram · Ceftibuten · Ceftiolene · Ceftizoxime · oxacephem (Flomoxef, Latamoxef ^‡)

4th	Cefepime · Cefozopran · Cefpirome · Cefquinome

5th	Ceftobiprole

Veterinary	Ceftiofur · Cefquinome · Cefovecin

Monobactams

Aztreonam · Tigemonam

β-lactamase inhibitors

penam (Sulbactam, Tazobactam) · clavam (Clavulanic acid)

Combinations

Co-amoxiclav (Amoxicillin/clavulanic acid)^# · Imipenem/cilastatin^# · Ampicillin/sulbactam (Sultamicillin) · Piperacillin/tazobactam

Other

polymyxins/detergent (Colistin, Polymyxin B) · depolarizing (Daptomycin) · hydrolyze NAM-NAG (Lysozyme)

^#WHO-EM. ^‡Withdrawn from market. CLINICAL TRIALS: ^†Phase III. ^§Never to phase III

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