Pelger-Huet anomaly is a blood laminopathy associated with the lamin B receptor.[1]
It is characterized by a white blood cell type known as a neutrophil whose nucleus is hyposegmented.
It is a genetic disorder with an autosomal dominant inheritance pattern. Heterozygotes are clinically normal, although their neutrophils may be mistaken for immature cells which may cause mistreatment in a clinical setting. Homozygotes tend to have neutrophils with rounded nuclei that do have some functional problems.
[edit] References
Pelger-Huet anomaly has an autosomal dominant pattern of
inheritance.
