Paul Byrne may refer to: - Paul Byrne (footballer born 1965), Irish footballer
- Paul Byrne (footballer born 1972), Irish footballer, former Celtic and Southend United player
- Paul Byrne (footballer born 1982), South African footballer, former Port Vale player
- Paul Byrne (footballer born 1986), Irish football player currently at Bray Wanderers
- Paul Byrne (journalist) (born 1978), Irish journalist, formerly of the BBC and Russia Today
- Paul Byrne, academic and president of Grant MacEwan University
- Paul Byrne, Australian gold medalist at the 1994 World Junior Championships in Athletics
- Paul Byrne, drummer and percussionist with In Tua Nua and Máire Brennan
- Paul Byrne, politician who ran in the Washington State Senate elections, 2006
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