PS2 or PS/2 may refer to:
- PlayStation 2, a sixth-generation video game console made by Sony
- IBM Personal System/2 (IBM PS/2), a series of personal computers introduced in 1987
- PS/2 connector, an interface standard for PC mice and keyboards, introduced with the IBM PS/2
- PostScript Level 2, the second version of the page description language
- Phantasy Star II, the second installment of the Phantasy Star series of video games
- Pokémon Stadium 2 (Japan), the second Pokémon Stadium video game for the Nintendo 64 in Japan, also known as Pokémon Stadium in North America
- Pokémon Stadium 2 (North America), the third Pokémon Stadium video game, also known as Pokémon Stadium Kin Gin in Japan
- Power Stone 2, the sequel to Power Stone for the Sega Dreamcast
- Photosystem II, a complex involved in photosynthesis