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Oxygen-18 (18O) is a natural, stable isotope of oxygen and one of the environmental isotopes. 18O is an important precursor for the production of fluorodeoxyglucose (FDG) used in positron emission tomography (PET). Generally, in the radiopharmaceutical industry, enriched water (H218O) is bombarded with hydrogen ions in either a cyclotron or linear accelerator creating fluorine-18. This is then synthesized into FDG and injected into a patient. [edit] PaleoclimatologyIn ice cores, mainly Arctic and Antarctic, the ratio O-18/O-16 (δ18O) can be used to determine the temperature of precipitation through time. Assuming that atmospheric circulation and elevation has not changed significantly over the poles, the temperature of ice formation can be calculated as equilibrium fractionation between phases of water is known for different temperatures. Water molecules are also subject to Rayleigh fractionation as atmospheric water moves from the equator poleward which results in progressive depletion of O-18, or lower δ18O values. In the 1950s, Harold Urey performed an experiment in which he mixed both normal water and water with oxygen-18 in a barrel, and then partially froze the barrel's contents.
Where t is temperature in Celsius and A and B are constants. [edit] See also
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