Oxprenolol Information & Oxprenolol Links at HealthHaven.com

Oxprenolol
Systematic (IUPAC) name
	(RS)-1-[2-(allyloxy)phenoxy]-3-(isopropylamino)propan-2-ol
Identifiers
CAS number	6452-71-7
ATC code	C07AA02
PubChem	4631
Chemical data
Formula	C15H23NO3
Mol. mass	265.348
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	20-70%
Metabolism	Hepatic
Half life	1-2hours
Excretion	Renal; Lactic (In lactiferous females)
Therapeutic considerations
Pregnancy cat.	C(AU)
Legal status	℞ Prescription only
Routes	oral
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Oxprenolol (Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris and abnormal heart rhythms. It is also used for treating high blood pressure.

Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol.^[1]

Oxprenolol is a potent beta-blocker and should not be administered to asthmatics because it can cause irreversible airway failure and inflammation.^{[citation needed]}

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[edit] References

^ McDevitt DG (1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". Eur. Heart J. 8 Suppl M: 9–14. PMID 2897304.

[0] McDevitt DG (1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". Eur. Heart J. 8 Suppl M: 9–14. PMID 2897304.

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