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Oxotremorine:
Oxotremorine
Systematic (IUPAC) name
1-[4-[(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone
Identifiers
CAS number 70-22-4
ATC code  ?
PubChem  ?
Chemical data
Formula C12H18N2O 
Mol. mass 206.28
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Oxotremorine is a synthetic alkaloid and is a muscarinic agonist[1] in that it will bind to muscarinic acetylcholine receptors. It is therefore a parasympathomimetic.

Specifically, oxotremorine is a non-selective muscarinic receptor agonist.

In addition, it also produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs. [2]

[edit] References

  1. ^ Tang C, Castoldi AF, Costa LG (April 1993). "Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes". Biochem. Mol. Biol. Int. 29 (6): 1047–54. PMID 8330013. 
  2. ^ Craig, C. R., Stitzel, R. E., Modern Pharmacology. Little, Brown. Boston, 2006.


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