Oxolinic acid

Systematic (IUPAC) name
5-Ethyl- 8-oxo- 5,8-dihydro [1,3] dioxolo [4,5-g] quinoline- 7-carboxylic acid
Identifiers
CAS number	14698-29-4
ATC code	J01MB05
PubChem	4628
Chemical data
Formula	C13H11NO5
Mol. mass	261.23 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?
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Oxolinic acid is a quinolone antibiotic.^[1] Dosages 12-20mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA-gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.^[2]

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[edit] See also

• Amfonelic acid
• Fluoroquinolone

[edit] References

v • d • e Antibacterials: nucleic acid inhibitors (J01E, J01M) Antifolates (inhibits purine metabolism, thereby inhibiting DNA and RNA synthesis) DR inhibitor 2,4-Diaminopyrimidine (Trimethoprim#, Brodimoprim, Tetroxoprim, Iclaprim†) Sulfonamides (DS inhibitor) Short- acting Sulfaisodimidine · Sulfamethizole · Sulfadimidine · Sulfapyridine · Sulfafurazole · Sulfanilamide (Prontosil) · Sulfathiazole · Sulfathiourea Intermediate- acting Sulfamethoxazole · Sulfadiazine# · Sulfamoxole Long- acting Sulfadimethoxine · Sulfalene · Sulfametomidine · Sulfametoxydiazine · Sulfamethoxypyridazine · Sulfaperin · Sulfamerazine · Sulfaphenazole · Sulfamazone Other/ungrouped sulfanilamide (Sulfacetamide, Sulfametrole) Combinations Sulfamethoxazole and trimethoprim# Topoisomerase inhibitors/ quinolones/ (inhibits DNA replication) 1st generation Cinoxacin‡ · Flumequine · Nalidixic acid · Oxolinic acid · Pipemidic acid · Piromidic acid · Rosoxacin Fluoroquinolones 2nd generation Ciprofloxacin#  · Enoxacin‡ · Fleroxacin‡ · Lomefloxacin · Nadifloxacin · Ofloxacin · Norfloxacin · Pefloxacin · Rufloxacin 3rd generation Balofloxacin · Grepafloxacin‡ · Levofloxacin · Pazufloxacin · Sparfloxacin‡ · Temafloxacin‡ · Tosufloxacin 4th generation Besifloxacin · Clinafloxacin† · Garenoxacin · Gemifloxacin · Moxifloxacin · Gatifloxacin‡ · Sitafloxacin · Trovafloxacin‡/Alatrofloxacin‡ · Prulifloxacin Veterinary Danofloxacin · Difloxacin · Enrofloxacin · Ibafloxacin · Marbofloxacin · Orbifloxacin · Pradofloxacin · Sarafloxacin Related agents (DG) Aminocoumarins: Novobiocin Anaerobic DNA inhibitors Nitro- imidazole derivatives Metronidazole#  · Tinidazole · Ornidazole Nitrofuran derivatives Nitrofurantoin#  · Nifurtoinol RNA synthesis Rifamycins/ RNA polymerase Rifampicin · Rifabutin · Rifapentine · Rifaximin #WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III