OSU can stand for:

• Institutions of higher education:
  • The Ohio State University
  • Oklahoma State University
  • Oregon State University
  • Oswego State University (formerly State University of New York (SUNY) at Oswego)
• The Order of St. Ursula or Ursulines (Roman Catholic Christian religious order)
• Osu, Ghana, a district in Accra
• Vought OSU US Navy Observation-Scout aircraft

• Japanese culture:
  • Osu!! Karate Bu (manga)
  • Osu! Tatakae! Ouendan (Nintendo rhythm game)
  • osu! (a freeware clone of Osu! Tatakae! Ouendan)
  • Japanese for "Patience with myself and others" used in karate
    • Also used in JIKC, Kyokushin, and Wado-ryu Karate.
• Operation Straight Up, an evangelical organization that provides faith-based entertainment to the United States military
• Igbo culture:
  • Osu caste system, a caste system practicesd by the Igbo people in West Africa

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