Osaka or Ōsaka may refer to:

• Osaka (大阪市, Ōsaka-shi^?), Japan's second largest city by population
• Osaka Prefecture (大阪府, Ōsaka-fu^?), Japan's second smallest prefecture by area

Osaka may also refer to:

• People:
  • Carlos Kasuga Osaka, a Mexican businessman

• Typeface:
  • Osaka (typeface), a typeface used in Macintosh

• Fictional characters (大阪 Ōsaka):
  • Ayumu Kasuga, a fictional character from Azumanga Daioh, nicknamed "Osaka"
  • Naru Osaka, a character from Sailor Moon

• Locations:
  • Places called Osaka (小坂, meaning "small hill"):
    • Osaka, Chiba
    • Osaka, Gifu, a former town
    • Osaka, Gunma
    • Osaka, Hiroshima
    • Osaka, Hyōgo
    • Osaka, Ibaraki
    • Osaka, Kanagawa
    • Osaka, Kumamoto
    • Osaka, Miyagi
    • Osaka, Nagano
    • Osaka, Ōita
    • Osaka, Okayama
    • Osaka, Shimane
    • Osaka, Shizuoka
    • Osaka, Wakayama
  • Places called Osaka (尾坂, meaning "foothill"):
    • Osaka, Kyōto
    • Osaka, Okayama
  • Places called Osaka (男坂, meaning "male hill"):
    • Osaka, Nara
  • Places called Osaka (御坂, meaning "honorable hill" or "hill of governing"):
    • Osaka, Miyagi
  • Places called Ōsaka (大坂, meaning "great hill"):
    • Ōsaka, Aichi
    • Ōsaka, Fukui
    • Ōsaka, Fukushima
    • Ōsaka, Ibaraki
    • Ōsaka, Ishikawa
    • Ōsaka, Kyōto
    • Ōsaka, Shizuoka
    • Ōsaka, Tokushima
    • Ōsaka, Tōkyō (in Meguro-ku, Aobadai 3 & 4)
    • Ōsaka, Tottori
    • Ōsaka, Wakayama
  • Places called Ōsaka (逢坂, meaning "hill of meeting"):
    • Ōsaka, Ōsaka (an area within Osaka, the major city listed above)
    • Ōsaka, Shiga

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