Optimus Prime is a character from the Transformers franchise. The term can refer to:

• Optimus Prime (Transformers), the Generation 1 version of the character
• Optimus Prime (Unicron Trilogy), a version of the character from Transformers: Armada, Transformers: Energon and Transformers: Cybertron.
• Optimus Prime (other incarnations), various versions of the character from different continuities.

This article includes a list of related items that share the same name (or similar names).