OSI is primarily used as an abbreviation and has many meanings: [edit] General - OSI Pharmaceuticals,an American pharmaceutical company
- OSI Restaurant Partners, the restaurant and entertainment group that includes Outback Steakhouse
- OSI Systems a company that manufactures security scanners and medical equipment based in California
- Objective Systems Integrators a company providing Operational Support Systems
- Olomouc Summer Institute, an educational program for high-school students
- Ontario Swine Improvement, a pig breeding company based in Ontario, Canada
- Open Space Institute, an organization that seeks to preserve scenic, natural and historic landscapes
- Open Society Institute, a private charitable foundation established by George Soros to promote open societies around the world
- Ordnance Survey Ireland (Suirbhéireacht Ordanáis Éireann)
- Otto-Suhr-Institut, the political-science institute of the Free University of Berlin
- Operation Serve International is a non-denominational ministry established in 1983 with a passion to extend the Kingdom of God on earth.
- Options Symbology Initiative, a plan to change the way that exchange-traded options are named.
- Open Systems International, Inc., an automation software vendor for the electric, petroleum, transportation and water industries.
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