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Located in the medulla, the nucleus prepositus hypoglossi or NPH is part of the horizontal gaze holding system. It functions as a neural integrator.

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v • d • e Human brain: rhombencephalon, myelencephalon: medulla (TA A14.1.04, GA 9.767) Dorsal Surface Posterior median sulcus · Posterolateral sulcus · Area postrema · Vagal trigone · Hypoglossal trigone · Medial eminence Grey: Cranial nuclei afferent: GVA: VII,IX,X: Solitary/tract/Dorsal respiratory group · SVA: Gustatory nucleus · GSA: VIII-v (Lateral, Medial, Inferior) efferent: GSE: XII  · GVE: IX,X,XI: Ambiguus · SVE: X: Dorsal · IX: Inferior salivatory nucleus Grey: other Gracile nucleus · Cuneate nucleus · Accessory cuneate nucleus White: Sensory/ascending Sensory decussation  · Medial lemniscus · Inferior cerebellar peduncle (Juxtarestiform body) · Ascending dorsal longitudinal fasciculus · MLF, III, IV and VI White: Motor/descending Descending dorsal longitudinal fasciculus · MLF, III, IV and VI Ventral White: Motor/descending Motor decussation · Olivocerebellar tract · Rubro-olivary tract Grey matter Ventral respiratory group · Arcuate nucleus of medulla · Inferior olivary nucleus Surface Anterior median fissure · Antero-lateral sulcus · Olive · Pyramid Grey: Raphe/ reticular Reticular formation (Gigantocellular, Parvocellular, Ventral, Lateral, Paramedian) · Raphe nuclei (Obscurus, Magnus, Pallidus)