Nodule may refer to:

• Nodule (geology), a small knobbly rock or mineral cluster, such as a manganese nodule
• Nodule (medicine), a small aggregation of cells
• Nodule (dermatology), a lesion similar to a papule
• Root nodule, an outgrowth formed on the roots of legumes that house symbiotic bacteria that fix atmospheric nitrogen and provide it to the plant in exchange for carbon
• A feature of mollusc sculpture.

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