Nikolsky's sign Information & Nikolsky's sign Links at HealthHaven.com

^[1] Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky . Nikolsky's sign is positive when slight rubbing of the skin results in exfoliation of the skin's outermost layer.^[2]^[3]^[4]^[5]

It is almost always present in toxic epidermal necrolysis,^[6] A "positive" Nikolsky's sign is associated with pemphigus vulgaris. ^[7] Nikolsky's sign is useful in differentiating between pemphigus vulgaris (where it is present or positive) and bullous pemphigoid (where it is absent)

[edit] See also

[edit] References

^ Insert footnote text here
^ Moss C, Gupta E (September 1998). "The Nikolsky sign in staphylococcal scalded skin syndrome". Arch. Dis. Child. 79 (3): 290. PMID 9875032. PMC 1717681. http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=9875032.
^ "eMedicine - Pemphigus Foliaceus : Article by Robert A Schwartz". http://www.emedicine.com/derm/topic318.htm.
^ Nikolski PV. Materiali K.uchenigu o pemphigus foliaceus [doctoral thesis]. Kiev. 1896.
^ "MedilinePlus: Nikolsky’s sign". http://www.nlm.nih.gov/medlineplus/ency/article/003285.htm.
^ PMID 17161178
^ Ma, O. Emergency Medicine Manual. McGraw Hill. 2004.

[0] Insert footnote text here

[pmid9875032-1] Moss C, Gupta E (September 1998). "The Nikolsky sign in staphylococcal scalded skin syndrome". Arch. Dis. Child. 79 (3): 290. PMID 9875032. PMC 1717681. http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=9875032.

[urleMedicine_-_Pemphigus_Foliaceus_:_Article_by_Robert_A_Schwartz-2] "eMedicine - Pemphigus Foliaceus : Article by Robert A Schwartz". http://www.emedicine.com/derm/topic318.htm.

[3] Nikolski PV. Materiali K.uchenigu o pemphigus foliaceus [doctoral thesis]. Kiev. 1896.

[MedilinePlus:_Nikolsky.E2.80.99s_sign-4] "MedilinePlus: Nikolsky’s sign". http://www.nlm.nih.gov/medlineplus/ency/article/003285.htm.

[5] PMID 17161178

[6] Ma, O. Emergency Medicine Manual. McGraw Hill. 2004.

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