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An antigenic determinant is the molecular aspect or moiety of a molecule that lets an antibody complement it and thus by definition, makes the molecule an antigen (classified further, an immunogen within an organism).

A Protein can underlie further modification within a biochemical pathway such as glycosylation, phosphorylation or proteolysis. This, by altering the structure of the protein, can produce new epitopes which are called neoantigenic determinants as they give rise to new (lat. neo) antigenic determinants and require separate, specific antibodies for recognition.

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