There are 35 properties and districts listed on the National Register in the county.
| [3] | Landmark name[4] | Image | Date listed | Location | City or Town | Summary |
| 1 | Black Site | | 01978-11-21 November 21, 1978 | Address Restricted | Greenwood | |
| 2 | Black Site | | 01991-01-11 January 11, 1991 | Address Restricted | Sidon | |
| 3 | Boulevard Subdivision Historic District | | 01986-03-02 March 2, 1986 | Roughly bounded by Jeff Davis Ave., Poplar St., President Ave., and Grand Boulevard 33°31′50″N 90°11′16″W / 33.53056°N 90.18778°W / 33.53056; -90.18778 (Boulevard Subdivision Historic District) | Greenwood | |
| 4 | Building at 308 Lamar Street | | 01985-11-04 November 4, 1985 | 308 Lamar St. 33°31′11″N 90°10′40″W / 33.51972°N 90.17778°W / 33.51972; -90.17778 (Building at 308 Lamar Street) | Greenwood | |
| 5 | Building at 312 George Street | | 01985-11-04 November 4, 1985 | 312 George St. 33°31′9″N 90°10′43″W / 33.51917°N 90.17861°W / 33.51917; -90.17861 (Building at 312 George Street) | Greenwood | |
| 6 | Building at 710 South Boulevard | | 01985-11-04 November 4, 1985 | 710 South Boulevard 33°30′48″N 90°11′12″W / 33.51333°N 90.18667°W / 33.51333; -90.18667 (Building at 710 South Boulevard) | Greenwood | |
| 7 | Central Commercial and Railroad Historic District | | 01985-11-04 November 4, 1985 | Roughly bounded by Washington, Main, and Lamar Sts., Ave. F, Wardaman and Johnson Sts., and Cotton and Fulton Sts. 33°31′2″N 90°10′43″W / 33.51722°N 90.17861°W / 33.51722; -90.17861 (Central Commercial and Railroad Historic District) | Greenwood | |
| 8 | Cotton Row Historic District | | 01980-05-15 May 15, 1980 | Cotton, Front, Fulton, Howard, Main, and Market Sts. 33°31′14″N 90°10′59″W / 33.52056°N 90.18306°W / 33.52056; -90.18306 (Cotton Row Historic District) | Greenwood | |
| 9 | Falls Site (22LF507) | | 01986-05-01 May 1, 1986 | Address Restricted | Minter City | |
| 10 | First Methodist Church of Greenwood | | 01985-11-04 November 4, 1985 | 310 W. Washington St. 33°31′9″N 90°11′4″W / 33.51917°N 90.18444°W / 33.51917; -90.18444 (First Methodist Church of Greenwood) | Greenwood | |
| 11 | Fort Leflore | | 01979-04-04 April 4, 1979 | North of Greenwood off Mississippi Highway 7 33°33′6″N 90°10′26″W / 33.55167°N 90.17389°W / 33.55167; -90.17389 (Fort Leflore) | Greenwood | |
| 12 | Fort Pemberton Site | | 01973-06-19 June 19, 1973 | West of Greenwood off U.S. Route 49, E. 33°31′45″N 90°14′7″W / 33.52917°N 90.23528°W / 33.52917; -90.23528 (Fort Pemberton Site) | Greenwood | |
| 13 | Four Corners Historic District | | 01985-02-14 February 14, 1985 | Washington and Henderson Sts. 33°31′7″N 90°11′9″W / 33.51861°N 90.18583°W / 33.51861; -90.18583 (Four Corners Historic District) | Greenwood | |
| 14 | Greenwood High School | | 01985-11-04 November 4, 1985 | 400 Cotton St. 33°31′11″N 90°10′40″W / 33.51972°N 90.17778°W / 33.51972; -90.17778 (Greenwood High School) | Greenwood | |
| 15 | Itta Bena Historic District | | 02009-09-30 September 30, 2009 | Roughly bounded by Cemetery St. to the north, Lake Shore Dr. to the east, Lake Side St. to the south, and Dewey St. to the west 33°29′42.43″N 90°19′11.3″W / 33.4951194°N 90.319806°W / 33.4951194; -90.319806 (Itta Bena Historic District) | Itta Bena | |
| 16 | Keesler Bridge | | 01988-11-16 November 16, 1988 | Spans the Yazoo River at Fulton St. 33°31′18″N 90°11′3″W / 33.52167°N 90.18417°W / 33.52167; -90.18417 (Keesler Bridge) | Greenwood | |
| 17 | Lane's Chapel Site | | 01976-05-04 May 4, 1976 | Address Restricted | Money | |
| 18 | Marclare | | 01980-11-25 November 25, 1980 | River Rd. 33°31′19″N 90°13′17″W / 33.52194°N 90.22139°W / 33.52194; -90.22139 (Marclare) | Greenwood | |
| 19 | McLean Site (22LF513) | | 01988-04-06 April 6, 1988 | Address Restricted | Itta Bena | |
| 20 | Murphey Site | | 01993-11-10 November 10, 1993 | Address Restricted | Itta Bena | |
| 21 | Neill Archeological Site | | 01976-04-26 April 26, 1976 | Address Restricted | Whaley | |
| 22 | Provine House | | 01980-04-08 April 8, 1980 | 319 Grand Boulevard 33°31′39″N 90°11′13″W / 33.5275°N 90.18694°W / 33.5275; -90.18694 (Provine House) | Greenwood | |
| 23 | Rebecca Site | | 01991-01-11 January 11, 1991 | Address Restricted | Sidon | |
| 24 | River Road and Western Downtown Residential Historic District | | 01986-03-02 March 2, 1986 | Roughly bounded by River Rd., Dewey and Gillespie, Washington and Johnson, and 1st Sts. 33°31′4″N 90°11′20″W / 33.51778°N 90.18889°W / 33.51778; -90.18889 (River Road and Western Downtown Residential Historic District) | Greenwood | |
| 25 | Rosemary-Humphreys House | | 01985-11-04 November 4, 1985 | 1440 Grand Boulevard 33°32′20″N 90°11′33″W / 33.53889°N 90.1925°W / 33.53889; -90.1925 (Rosemary--Humphreys House) | Greenwood | |
| 26 | Southworth House | | 01985-11-04 November 4, 1985 | 1108 Mississippi Ave. 33°30′34″N 90°11′13″W / 33.50944°N 90.18694°W / 33.50944; -90.18694 (Southworth House) | Greenwood | |
| 27 | STAR OF THE WEST |  | 01975-05-21 May 21, 1975 | West of Greenwood on the Tallahatchie River 33°31′54″N 90°13′59″W / 33.53167°N 90.23306°W / 33.53167; -90.23306 (STAR OF THE WEST) | Greenwood | |
| 28 | Stratton Archeological Site | | 01999-07-28 July 28, 1999 | Address Restricted | Sidon | |
| 29 | Sweethome Mound | | 01978-06-09 June 9, 1978 | Address Restricted | Wakeland | |
| 30 | Wesley Memorial Methodist Episcopal | | 01985-11-04 November 4, 1985 | 800 Howard St. 33°30′49″N 90°10′52″W / 33.51361°N 90.18111°W / 33.51361; -90.18111 (Wesley Memorial Methodist Episcopal) | Greenwood | |
| 31 | Wesley Methodist Church Historic District | | 01999-04-08 April 8, 1999 | Roughly bounded by Cotton, Howard, Palace, Weeks Lane, and W. Johnson 33°30′41″N 90°10′54″W / 33.51139°N 90.18167°W / 33.51139; -90.18167 (Wesley Methodist Church Historic District) | Greenwood | |
| 32 | Whaley Archeological Site | | 01976-03-15 March 15, 1976 | Address Restricted | Whaley | |
| 33 | W.M. Whittington House | | 01984-07-19 July 19, 1984 | 401 E. Market St. 33°31′18″N 90°10′40″W / 33.52167°N 90.17778°W / 33.52167; -90.17778 (Whittington, W. M., House) | Greenwood | |
| 34 | Williams Landing and Eastern Downtown Residential Historic District | | 01986-03-02 March 2, 1986 | Roughly bounded by Front, McLemore and Lamar, Market, and George Sts. 33°31′15″N 90°10′38″W / 33.52083°N 90.17722°W / 33.52083; -90.17722 (Williams Landing and Eastern Downtown Residential Historic District) | Greenwood | |
| 35 | Wright House | | 01985-11-04 November 4, 1985 | 414 Fulton Ave. 33°31′2″N 90°10′59″W / 33.51722°N 90.18306°W / 33.51722; -90.18306 (Wright House) | Greenwood | |