N-Acetyl procainamide

Systematic (IUPAC) name
4-acetylamino-N-(2-diethylaminoethyl)benzamide
Identifiers
CAS number	32795-44-1
ATC code	?
PubChem	4342
Chemical data
Formula	C15H23N3O2
Mol. mass	277.36 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	intravenously or orally

N-Acetylprocainamide (NAPA or acecainide) is the N-acetylated metabolite of procainamide. It is a Class III antiarrhythmic agent.

It can be given either intravenously or orally, and is eliminated primarily by renal excretion. Comparative studies with other antiarrhythmic drugs have not been undertaken apart from a small study in atrial flutter where acecainide was better than quinidine plus digoxin. Although further clinical experience is required before the relative place of acecainide in therapy can be determined, the drug nevertheless appears to offer advantages over procainamide, particularly with respect to the reduced formation of antinuclear antibodies.

[edit] External links

• PubPK - N-Acetylprocainamide Pharmacokinetics

[edit] References

• Merck Index, 13th Edition, 20.
• Ger. Pat. , 1971, 2 062 978; CA , 75 , 76427, (Acecainide)