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Aztreonam. (The square is the beta-lactam. There is a second thiazole ring, but it is not fused to the beta-lactam ring)

Monobactams are beta-lactam compounds wherein the beta-lactam ring is alone and not fused to another ring (in contrast to most other beta-lactams, which have at least two rings). They work only against Gram-negative bacteria.[citation needed]

The only commercially available monobactam antibiotic is aztreonam.

Other examples of monobactams are tigemonam,[1] nocardicin A, and tabtoxin.

[edit] References

  1. ^ Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro antimicrobial activity of tigemonam, a new orally administered monobactam". Antimicrob. Agents Chemother. 32 (3): 346–9. PMID 3259122. PMC 172173. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=3259122. 

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