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Molindone
Systematic (IUPAC) name
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-
1,5,6,7-tetrahydro-4H-indol-4-one
Identifiers
CAS number 7416-34-4
ATC code N05AE02
PubChem 23897
Chemical data
Formula C16H24N2O2 
Mol. mass 276.374 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 1.5 hours
Excretion Minor, renal and fecal
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status

-only(US)

Routes Oral


Molindone is a therapeutic antipsychotic, used in the treatment of schizophrenia.[1] It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken by mouth.

Molindone is sold under the product name Moban.

[edit] Adverse effects

The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.[2][3]

[edit] See also

[edit] References

  1. ^ "molindone" (web). F.A. Davis Company. http://www.drugguide.com/monograph_library/psychotropic_drugs/molindone.htm. Retrieved 2007-11-04. 
  2. ^ Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). "Molindone for schizophrenia and severe mental illness". Cochrane Database Syst Rev (1): CD002083. doi:10.1002/14651858.CD002083.pub2. PMID 17253473. 
  3. ^ Allison DB, Mentore JL, Heo M, et al. (1999). "Antipsychotic-induced weight gain: a comprehensive research synthesis". Am J Psychiatry 156 (11): 1686–96. PMID 10553730.  Free full text



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