The Minister of National Defence is also the designated Lead Minister for Search and Rescue (LMSAR) within the federal government.
| 1. | George Perry Graham | Cabinet of King | January 1, 1923 – April 27, 1923 |
| * | Edward Mortimer Macdonald (Acting) | Cabinet of King | April 28, 1923 – August 16, 1923 |
| 2. | Edward Mortimer Macdonald | Cabinet of King | August 17, 1923 – June 28, 1926 |
| * | Hugh Guthrie (Acting) | Cabinet of Meighen | June 29, 1926 – July 12, 1926 |
| 3. | Hugh Guthrie | Cabinet of Meighen | July 13, 1926 – September 25, 1926 |
| vacant | Cabinet of King | September 25, 1926 – September 30, 1926 |
| * | James Robb (Acting) | Cabinet of King | October 1, 1926 – October 7, 1926 |
| 4. | James Ralston | Cabinet of King | October 8, 1926 – August 7, 1930 |
| 5. | Donald Matheson Sutherland | Cabinet of Bennett | August 7, 1930 – November 16, 1934 |
| 6. | Grote Stirling | Cabinet of Bennett | November 17, 1934 – October 23, 1935 |
| 7. | Ian Alistair Mackenzie | Cabinet of King | October 24, 1935 – September 18, 1939 |
| 8. | Norman McLeod Rogers | Cabinet of King | September 19, 1939 – June 10, 1940 |
| * | Charles Power (Acting) | Cabinet of King | June 11, 1940 – July 4, 1940 |
| James Ralston (2nd time) | Cabinet of King | July 5, 1940 – November 1, 1944 |
| 9. | Andrew McNaughton | Cabinet of King | November 2, 1944 – August 20, 1945 |
| 10. | Douglas Abbott | Cabinet of King | August 21, 1945 – December 9, 1946 |
| 11. | Brooke Claxton | Cabinet of King | December 10, 1946 – November 15, 1948 |
| Cabinet of St–Laurent | November 15, 1948 – June 30, 1954 |
| 12. | Ralph Campney | Cabinet of St–Laurent | July 1, 1954 – June 20, 1957 |
| 13. | George Pearkes | Cabinet of Diefenbaker | June 21, 1957 – October 10, 1960 |
| 14. | Douglas Harkness | Cabinet of Diefenbaker | October 11, 1960 – February 3, 1963 |
| vacant | Cabinet of Diefenbaker | February 4, 1963 – February 11, 1963 |
| 15. | Gordon Churchill | Cabinet of Diefenbaker | February 12, 1963 – April 21, 1963 |
| 16. | Paul Hellyer | Cabinet of Pearson | April 22, 1963 – September 18, 1967 |
| 17. | Léo Cadieux | Cabinet of Pearson | September 1967 – April 19, 1968 |
| Cabinet of Trudeau | April 20, 1968 – September 16, 1970 |
| * | Bud Drury (Acting) | Cabinet of Trudeau | September 17, 1970 – September 23, 1970 |
| 18. | Donald Macdonald | Cabinet of Trudeau | September 24, 1970 – January 27, 1972 |
| 19. | Edgar Benson | Cabinet of Trudeau | January 28, 1972 – August 31, 1972 |
| * | Jean-Eudes Dubé (Acting) | Cabinet of Trudeau | September 1, 1972 – September 6, 1972 |
| * | Bud Drury (Acting) (2nd time) | Cabinet of Trudeau | September 7, 1972 – November 26, 1972 |
| 20. | James Richardson | Cabinet of Trudeau | November 27, 1972 – October 12, 1976 |
| * | Barnett Danson (Acting) | Cabinet of Trudeau | October 13, 1976 – November 2, 1976 |
| 21. | Barnett Danson | Cabinet of Trudeau | November 3, 1976 – June 3, 1979 |
| 22. | Allan McKinnon | Cabinet of Clark | June 4, 1979 – March 2, 1980 |
| 23. | Gilles Lamontagne | Cabinet of Trudeau | March 3, 1980 – August 11, 1983 |
| 24. | Jean–Jacques Blais | Cabinet of Trudeau | August 12, 1983 – June 29, 1984 |
| Cabinet of Turner | June 30, 1984 – September 16, 1984 |
| 25. | Robert Coates | Cabinet of Mulroney | September 17, 1984 – February 11, 1985 |
| * | Erik Nielsen (Acting) | Cabinet of Mulroney | February 12, 1985 – February 25, 1985 |
| 26. | Erik Nielsen | Cabinet of Mulroney | February 26, 1985 – June 29, 1986 |
| 27. | Perrin Beatty | Cabinet of Mulroney | June 30, 1986 – January 29, 1989 |
| 28. | Bill McKnight | Cabinet of Mulroney | January 30, 1989 – April 20, 1991 |
| 29. | Marcel Masse | Cabinet of Mulroney | April 21, 1991 – January 3, 1993 |
| 30. | Kim Campbell | Cabinet of Mulroney | January 4, 1993 – June 24, 1993 |
| 31. | Tom Siddon | Cabinet of Campbell | June 25, 1993 – November 3, 1993 |
| 32. | David Collenette | Cabinet of Chrétien | November 4, 1993 – October 4, 1996 |
| 33. | Doug Young | Cabinet of Chrétien | October 5, 1996 – June 10, 1997 |
| 34. | Art Eggleton | Cabinet of Chrétien | June 11, 1997 – June 25, 2002 |
| 35. | John McCallum | Cabinet of Chrétien | June 26, 2002 – December 11, 2003 |
| 36. | David Pratt | Cabinet of Martin | December 12, 2003 – July 19, 2004 |
| 37. | Bill Graham | Cabinet of Martin | July 20, 2004 – February 5, 2006 |
| 38. | Gordon O'Connor | Cabinet of Harper | February 6, 2006 – August 14, 2007 |
| 39. | Peter MacKay | Cabinet of Harper | August 14, 2007 – |