Metrifonate

Systematic (IUPAC) name
(RS)-2,2,2-trichloro-1-dimethoxyphosphoryl-ethanol
Identifiers
CAS number	52-68-6
ATC code	P02BB01 QP52AB01 QP53AF02
PubChem	5853
Chemical data
Formula	C4H8Cl3O4P
Mol. mass	257.436 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?
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Metrifonate (INN) or trichlorfon (USAN) is an organophosphate acetylcholinesterase inhibitor.

It is classified as irreversible.^[1]

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.^[2]

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.^[3]

[edit] References

v • d • e Parasympathomimetics / cholinergic agonists / acetylcholinesterase inhibitors (N06DA, N07AA) Direct (at receptor) muscarinic: Muscarine  · Oxotremorine  · M1 (Vedaclidine • Xanomeline)  · M3 (Bethanechol, Pilocarpine, Arecoline, Cevimeline, Aceclidine, Alvameline)  · Methacholine nicotinic: Nicotine (low doses) · Lobeline · Varenicline · Epibatidine  · Dimethylphenylpiperazinium M & N: Acetylcholine/Choline alfoscerate · Carbachol Indirect/AIs (in synapse) Reversible very short acting: Edrophonium carbamates/stigmine: Ambenonium · Rivastigmine · Distigmine · tertiary/CNS (Physostigmine) · quaternary/peripheral (Neostigmine, Pyridostigmine) anti-dementia (Galantamine, Donepezil, Tacrine, Ladostigil) Irreversible/ organophosphate ophthalmological (Ecothiopate, Isoflurophate, Demecarium) antiparasitic (Malathion, Metrifonate) chemical warfare (see Nerve agent)

v • d • e Antiparasitics – Anthelmintics (P02) Antiplatyhelmintic agents Antitrematodals (schistosomicides) Binds tubulin benzimidazole (Triclabendazole#) AI phosphonic acid (Metrifonate) Other/unknown quinoline (Praziquantel#, Oxamniquine#) · phenol (Bithionol) · thiazole (Niridazole) · arylsulfonate (Stibophen) Anticestodals (taeniacides) Binds tubulin benzimidazole (Albendazole#) Other/unknown salicylanilide (Niclosamide)# · aminoacridine (Quinacrine) · butyrophenone (Desaspidin) · chlorophenol (Dichlorophen) Antinematodal agents (macrofilaricides) Binds tubulin benzimidazole (Mebendazole#, Thiabendazole, Albendazole#, Fenbendazole, Ciclobendazole, Flubendazole) Chloride channel macrolide (Ivermectin#) NMDA tetrahydropyrimidine (Pyrantel#, Pyrantel pamoate, Oxantel) Other/unknown piperazine (Piperazine · Diethylcarbamazine#) · thiazole (Levamisole#) · quinolinium (Pyrvinium) · benzylammonium (Bephenium) · naphthalenesulfonate (Suramin#)  · Tribendimidine #WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III see also diseases

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