Memory RNA is a now-discredited^{[citation needed]} hypothetical form of RNA that was proposed by James V. McConnell and others as a means of explaining how long-term memories were stored in the brain.^{[citation needed]} The concept behind it was that since RNA encoded information, and since living cells could produce and modify RNA in reaction to external events, it might also be used in neurons to record stimuli.^{[citation needed]}

One experiment that was purported to show a chemical basis for memory involved training planaria to solve an extremely simple "maze", then grinding them up and feeding them to untrained planaria to see if they would be able to learn more quickly. The experiment seemed to show such an effect, but it was later determined that the original planaria had left chemical tracks inside the maze itself that were not properly cleaned away before the next set of planaria were run.^{[citation needed]}

[edit] Memory RNA in science fiction

Memory RNA made some appearances in the science fiction of the time, often in the form of "skill pills" containing memory RNA that provided the consumer with new skills, or in the context of mind transfer. This concept shows up in several of Larry Niven's short stories and various episodes of The Invisible Man (2000 TV series).

A few Star Trek novels during the 1980s employed memory RNA as a plot device to allow a character to rapidly learn an alien language, in the form of an "RNA drip".

The basic principle or the Memory RNA was also used by comic book writer Alan Moore to explain the origin of DC Comics' character the Swamp Thing in Saga of the Swamp Thing #21. In the story, believing the creature to be dead, a scientist super-villain performs an autopsy on the Swamp Thing and discovers that it is not scientist Alec Holland turned into a plant mutant, but swamp vegetation that after eating the mortal remains of Holland, had absorbed his mind, knowledge, memories, and skills and created a new sentient being that believed itself to be Alec Holland. The planaria experiment is used in the story to back this theory.

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