A megakaryoblast is a precursor cell to a promegakaryocyte, which in turn becomes a megakaryocyte during haematopoiesis. It is the beginning of the thrombocytic series.

It derives from a CFU-Me colony unit of pluripotential hemopoietic stem cells. (Some sources use the term "CFU-Meg" to identify the CFU.^[1])

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v • d • e Myeloid physiology Hematopoiesis Myelopoiesis (CFU-GEMM) CFU-GM Granulopoiesis (Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, Band cell) Monocytopoiesis (Monoblast, Promonocyte) MEP Thrombopoiesis (Megakaryoblast, Promegakaryocyte) Erythropoiesis (Proerythroblast, Normoblast, Reticulocyte) General Extramedullary hematopoiesis Hemostasis Coagulation (Fibrinolysis) · Clot retraction · Platelet adhesiveness myeloid navs: cells/physio, disease of RBCs+megakaryocytes/monocytes+granulocytes/neoplasia, symptoms+signs/eponymous

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