Mark Hughes may refer to:

• Mark Hughes, Welsh football player
• Mark Hughes (Emmerdale), fictional character on the ITV soap opera Emmerdale
• Mark Hughes (basketball), American basketball player and coach
• Mark Hughes (English footballer) (born 1986), English footballer
• Mark Hughes (Northern Irish footballer) (born 1983), Northern Irish footballer
• Mark Hughes (politician), MP for the city of Durham, 1970–1983
• Mark R. Hughes, founder of the multi-level marketing nutritional company Herbalife
• Mark Hughes (rugby league), Australian former professional rugby league player who played for the Newcastle Knights
• Mark Hughes (fighter), mixed martial arts fighter and identical twin brother of two-time UFC welterweight champion Matt Hughes
• Mark Hughes (journalist), English Formula One journalist

This disambiguation page lists articles associated with the same personal name. If an internal link led you here, you may wish to change the link to point directly to the intended article.