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Mitofusin 2
Identifiers
Symbols	MFN2; CMT2A; CMT2A2; CPRP1; HSG; KIAA0214; MARF
External IDs	OMIM: 608507 MGI: 2442230 HomoloGene: 8915 GeneCards: MFN2 Gene
Gene ontology Molecular function • nucleotide binding • GTPase activity • GTP binding • hydrolase activity Cellular component • mitochondrion • mitochondrial outer membrane • cytosol • membrane • integral to membrane • outer membrane • intrinsic to mitochondrial outer membrane Biological process • protein targeting to mitochondrion • mitochondrial membrane organization and biogenesis • cell cycle arrest • mitochondrial fusion • negative regulation of Ras protein signal transduction • negative regulation of smooth muscle cell proliferation • mitochondrion localization
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9927	170731
Ensembl	ENSG00000116688	ENSMUSG00000029020
UniProt	O95140	Q3TEX7
RefSeq (mRNA)	NM_014874	XM_001002345
RefSeq (protein)	NP_055689	XP_001002345
Location (UCSC)	Chr 1: 11.96 - 12 Mb	Chr 4: 146.72 - 146.75 Mb
PubMed search	[1]	[2]

Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene.^[1][2]

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein may play a role in the pathophysiology of obesity.^[3]

[edit] References

[edit] Further reading

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