Lyse can refer to:

• Lyse Abbey, a former Cistercian abbey in Norway
• Łyse, Masovian Voivodeship, a village in east-central Poland
• Łyse, Podlaskie Voivodeship, a village in north-east Poland
• lysis, the death of a cell by bursting
• Lyse (mythology), daughter of Thespius and Megamede in Greek mythology, who bore Heracles a son, Eumedes
• Lyse Energi
• Another name of Lysebotn

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