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Louis D. Astorino (born 1948) is an architect in Pittsburgh, Pennsylvania who was architect of several high profile buildings in his hometown and is the first American architect to design a building in the Vatican.

He was born in Pittsburgh and received a bachelors from Pennsylvania State University in 1969. In 1972 he started his own firm named L. D. Astorino & Associates.[1] It would subsequently be named Astorino.[2]

He was introduced to the international stage in 1996 when Gateway Clipper Fleet founder John E. Connelly introduced him as a prospective architect for the Domus Sanctae Marthae that Pope John Paul II wanted to build to house cardinals during the selection of popes. Connelly was offering to finance the project. Connelly's design was ultimately rejected but he was kept on as supervisory architect. He would later design the adjoining Chapel of the Holy Spirit.[3] Astorino's firm designed the new Children's Hospital of Pittsburgh completed in 2009 at a cost of $622 million. [4]

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