Orbitoclast instruments used in transorbital lobotomy^[1]

Lobotomy (Greek: λοβός — lobos: "lobe (of brain)", τομή — tome: "cut/slice") is a neurosurgical procedure, a form of psychosurgery, also known as a leukotomy or leucotomy (from Greek λευκός — leukos "clear/white" and tome). It consists of cutting the connections to and from the prefrontal cortex, the anterior part of the frontal lobes of the brain. Whilst the procedure, initially termed a leucotomy, has been controversial since its inception in 1935, it was for more than two decades a mainstream medical procedure employed to relieve the symptoms of psychiatric and, occassionally, other conditions. This was so despite the acceptance in the psychiatric, neurological and wider medical culture that the procedure often produced serious side-effects. The heyday of its usage was from the early 1940s until the mid-1950s when modern neuroleptic (antipsychotic) medications were introduced. By 1951 almost 20,000 lobotomies had been performed in the United States. The decline of the procedure was gradual rather than precipitous. In Ottawa's psychiatric hospitals, for instance, 58 lobotomies were performed in 1961, seven years after the arrival in Canada of the antipsychotic drug chlorpromazine in 1954. However, this did mark a decline from the 153 lobotomies performed in the same hospitals in 1953.^[2]

[edit] Context

The lobotomy was one of a series of radical and invasive physical therapies developed in Europe in the first half of the twentieth century. These psychiatric innovations signalled a break with an asylum culture of therapeutic nihilism which had prevailed due to the fact that most serious forms of mental illness were regarded as degenerative hereditary disorders and hence unamenable to treatment.^[3] These new "heroic" physical therapies of the early twentieth century include: malarial therapy for general paralysis of the insane (1917);^[4] barbituate induced deep sleep therapy (1920); insulin shock therapy (1933); cardiazol shock therapy (1934); and electroconvulsive therapy (1938).^[5]

In relation to the development of the leucotomy procedure by Moniz in 1936, it is important to remember that all of the above therapeutic interventions were extreme and experimental forms of therapy and that most posed serious risks to the health of the patients who underwent them. Leucotomy was seen by many psychiatrists as no more severe than therapies such as insulin or cardiazol shock^[6] and, indeed, these apparently successful procedures conceived for the treatment of patients suffering severe mental illnesses helped to create the intellectual climate and medical and social warrants that allowed a surgical procedure as radical and irreversible as leucotomy to appear as a viable and even necessary proposition. Moreover, Joel Braslow argues that from malarial therapy onward to lobotomy, physical psychiatric therapies "spiral closer and closer to the interior of the brain" with this organ increasingly taking "centre stage as a source of disease and site of cure."^[7] For Roy Porter, these often violent and invasive psychiatric interventions are indicative of both the well-intentioned desire of psychiatrists to find some medical means of alleviating the suffering of the thousands of patients in psychiatric hospitals in the twentieth century and also the relative lack of social power of those self-same patients to resist the increasingly radical and even reckless interventions of asylum doctors.^[8]

[edit] Pioneers

[edit] Gottlieb Burckhardt

In December 1888 Gottlieb Burckhardt, a psychiatrist with little experience of surgery, made one of the first forays into the field of psychosurgery when he operated on six patients, two women and four men aged between 26 and 51, in a private psychiatric hospital in Switzerland. Their diagnoses were, variously, one of chronic mania, one of primary dementia and four of original paranoia (primäre Verrücktheit, an obsolete diagnostic category sometimes anachronistically equated with schizophrenia) and, according to Burckhardt's case notes, they exhibited serious psychiatric symptoms such as auditory hallucinations, paranoid delusions, aggression, excitement and violence. He operated on the frontal, temporal, and tempoparietal lobes of these patients. The results were not overly encouraging as one patient died five days after the operation after experiencing epileptic convulsions, one improved but later committed suicide, another two showed no change, and the last two patients became "quieter". This equated to a success rate of 50%. Complications consequent to the procedure included epilepsy (in two patients), motor weakness, "word deafness" and sensory aphasia. Only two patients are recorded as having no complications.^[9]

The theoretical basis of Burckhardt's action rested on three propositions. The first was that mental illness had a physical basis and that disordered minds were merely a reflection of disordered brains. Next, the associationist viewpoint of nerve functioning which conceived the nervous system as operating according to the following three fold division of labour: an input (or sensory or afferent) system, a connecting system which processed information and an output (or efferent or motor) system. The final assumption of Buckhardt's was that the brain was modular which meant that each mental module or mental faculty could be linked to a specific location in the brain. In accordance with such a viewpoint Buckhardt postulated that lesions in specific areas of the brain might impact on behaviour in a specific manner.In other words, he thought that by cutting the connecting system, or second association state of brain's system of communication troubling symptoms might be alleviated without compromising either the nervous system's input or output systems. The procedure was aimed at relieving symptoms not at curing a given mental disease. ^[10] Thus, he wrote in 1891:

[I]f excitation and impulsive behaviour are due to the fact that from the sensory surfaces excitations abnormal in quality, quantity and intensity do arise, and do act on the motor surfaces, then an improvement could be obtained by creating an obstacle between the two surfaces. The extirpation of the motor or the sensory zone would expose us to the risk of grave functional disturbances and to technical difficulties. It would be more advantageous to practice the excision of a strip of cortex behind and on both sides of the motor zone creating thus a kind of ditch in the temporal lobe.^[11]

Burkhardt attended the Berlin Medical Conference of 1889, which was also attended by such heavyweight alienists as Victor Horsely, Valentine Magnan and Emil Kraepelin, and presented a paper on his brain operations. Whilst his findings were subsequently widely reported in the psychiatric literature, the reviews were unremittingly negative and there was much ill ease generated by the surgical procedures he had performed.^[12] Kraepelin, writing in 1893, was scathing of Burckhardt's attempts, and stated that "he [Burkhardt] suggested that restless patients could be pacified by scratching away the cerebral cortex."^[13] Whilst Giuseppe Seppilli, the Italian professor of neuropsychiatry, remarked in 1891 that Burkhardt's view of the brain as modular did not "fit in well with the view held by most [experts] that the psychoses reflect a diffuse pathology of the cerebral cortex and [ran counter to] the conception of the psyche as a unitary entity".^[14]

Burckhardt wrote in 1891 that "Doctors are different by nature. One kind adheres to the old principle: first, do no harm (primum non nocere); the other one says: it is better to do something than do nothing (melius anceps remedium quam nullum). I certainly belong to the second category".^[15] The response to this statement was provided by the French alienist Armand Semelaigne when he wrote that "an absence of treatment was better than a bad treatment".^[16] After the publication of his impressive 81 page monograph on the subject in 1891, Burkhardt ended his research and practice of psychosurgery no doubt in part due to the ridicule he received from his colleagues over the methods he had employed.^[17]

Commenting on his monograph in 1891 the British psychiatrist William Ireland provided a succinct summation of his position:

Dr. Burckhardt has a firm faith in the view that the mind is made up of a number of faculties, holding their seats in distinct portions of the brain. Where excess or irregularity of function occurs he seeks to check it by ablation of a portion of the irritated centres. He defends himself from the criticisms which are sure to be directed against his bold treatment by showing the desperate character of the prognosis of the patients upon whom the operations were performed ...^[18]

Ireland, however, doubted that any English psychiatrist would have the "hardihood" to follow the path taken by Burkhardt.^[19]

[edit] Egas Moniz

The next stage in the development of the procedure was provided by the Portuguese physician and neurologist António Egas Moniz, who was highly acclaimed for his work on cerebral angiography (radiographical visual of the blood vessels in the brain) in 1927.^[20] Despite having no clinical psychiatric experience and, indeed, little interest in psychiatry, in 1935 at the Hospital Santa Marta in Lisbon, he devised the surgery called prefrontal leucotomy which was carried out under his direction by the neurosurgeon Pedro Almeida Lima. He was also responsible for coining the term psychosurgery.^[21] The procedure involved drilling holes in the patient's head and destroying tissue in the frontal lobes by injecting alcohol. He later changed technique, using a surgical instrument called a leucotome that cut brain tissue by rotating a retractable wire loop (a quite different cutting instrument also used for lobotomies shares the same name).^[22] Between November 1935 and February 1936 Moniz and Lima operated on twenty patients, publishing their findings in the same year.^[23] Their own assessment was that 35% of the patients improved greatly, 35% improved moderately and that in the remaining 30% there was no change. The patients were aged between 27 and 62 years of age, twelve were female and eight were male. Nine of the patients were diagnosed as suffering from depression, six from schizophrenia, two from panic disorder, and one each from mania, catatonia and manic-depression with the most prominent symtpoms being anxiety and agitation. The duration of the illness prior to the procedure varied from as little as four weeks to as much as 22 years although all but four had been ill for at least one year. The post-operative follow-up assessment took place anywhere from one to ten weeks following surgery. The observed complications were less severe than in Burckhardt's sample as there were no deaths or epileptic convulsions and the most cited complication was fever.^[24]

The theoretical underpinnings of Moniz's avant guarde psychosurgery were largely commensurate with the nineteenth century ones that formed the basis of Burckhardt's theories before him. Although in his later writings he referenced both the neuron theory of Ramón y Cajal and the conditioned reflex of Ivan Pavlov in essenced he simply interpreted this new neurological research in terms of the old psychological theory of associationism. ^[25] Where he differed significantly from Burckhardt was in the fact that he did not think that there was any physical anatomical pathology in the brains of the mentally ill but rather that their neural pathways were caught in fixed and destructive circuits.^[26] As he wrote in 1936:

[The] mental troubles must have [...] a relation with the formation of cellulo-connective groupings, which become more or less fixed. The cellular bodies may remain altogether normal, their cylinders will not have any anatomical alterations; but their multiple liasons, very variable in normal people, may have arrangements more or less fixed, which will have a relation with persistent ideas and deliria in certain morbid psychic states.^[27]

Brain animation: left frontal lobe highlighted in red. Moniz targetted the frontal lobes in the leucotomy procedure which he first conceived in 1933.

The removal of these aberrant and fixed pathological brain circuits, therefore, might lead to some improvement in mental symptoms. Moniz believed that the brain would functionally adapt to such injury.^[28] A significant advantage of this approach was that, unlike the position adopted by Burckhardt, it was unfalsifiable according to the knowledge and technology of the time as the absence of a known correlation between physical brain pathology and mental illness could not disprove his thesis.^[29]

Traditionally, the question as to why Moniz targetted the frontal lobes is answered with regard to a presentation by John Fulton and Carlyle Jacobsen at the Second International Congress of Neurology held in London in 1935. Fulton and Carlyle presented two chimpanzees who had frontal lobectomies. The operation had a pacifying effect on the two primates who had previously suffered from behavioural disorders. It has been alleged that this provided the impetus and inspiration for Moniz to try the same technique on psychiatric patients.^[30] However, as Berrios points out, this conflicts with the fact that Moniz had told his colleague Lima in confidence as early as 1933 of his psychosurgical idea. Nor did he mention Fulton's and Carlyle's presentation as an influence when writing about the procedure in 1936.^[31] Indeed, as Kotowicz notes, his attention was drawn more to the case presented by Richard Brickner at the same conference of a patient who had had his frontal lobes ablated and, whilst experiencing a flattening of affect, had suffered no apparent diminution of intellect. Brickner had published on this case in 1932.^[32]

Moniz was given the Nobel Prize for medicine in 1949 for this work.^[33]

[edit] Walter Freeman

James Watts (left) and Walter Freeman performing a lobotomy

The American neurologist and psychiatrist Walter Freeman, who had also attended the London Congress of Neurology in 1935, was intrigued by Moniz's work, and with the help of his close friend, neurosurgeon James W. Watts, he performed the first prefrontal leucotomy in the United States in 1936 at the hospital of George Washington University in Washington.^[34] Freeman and Watts gradually refined the surgical technique, and created the Freeman-Watts procedure (the "precision method," the standard prefrontal lobotomy).

The Freeman-Watts prefrontal lobotomy still required drilling holes in the scalp, so surgery had to be performed in an operating room by trained neurosurgeons. Walter Freeman believed this surgery would be unavailable to those he saw as needing it most: patients in state mental hospitals having no operating rooms, surgeons, or anesthesia, and limited budgets. Freeman wanted to simplify the procedure so that it could be carried out by psychiatrists in mental asylums, which housed roughly 600,000 American inpatients at the time.

Inspired by the work of Italian psychiatrist Amarro Fiamberti, Freeman at some point conceived of approaching the frontal lobes through the eye sockets instead of through drilled holes in the skull. In 1945 he took an icepick^[35] from his own kitchen and began testing the idea on grapefruit^[36] and cadavers. This new "transorbital" lobotomy involved lifting the upper eyelid and placing the point of a thin surgical instrument (often called an orbitoclast or leucotome, although quite different from the wire loop leucotome described above) under the eyelid and against the top of the eyesocket. A mallet was used to drive the leucotome through the thin layer of bone and into the brain. The leucotome was then swept from side to side, thus severing the nerve fibers connecting the frontal lobes to the thalamus. (In a more radical variation, the butt of the leucotome was pulled upward, sending the tip farther back into the brain, producing a "deep frontal cut.") The leucotome was then withdrawn, and the procedure repeated on the other side.

Freeman performed the first transorbital lobotomy on a live patient in 1946. Its simplicity suggested the possibility of carrying it out in mental hospitals lacking the surgical facilities required for the earlier, more complex procedure (Freeman suggesting that, where conventional anesthesia was unavailable, electroconvulsive therapy be used to render the patient unconscious).^[37] In 1947, the Freeman and Watts partnership ended as the latter was disgusted by Freeman's modification of a the lobotomy from a surgical operation into a simple "office" procedure. Between 1940 and 1944 684 lobotomies were performed in the United States. However, due to the evangelical promotion of the technique by Freeman and Watts those numbers increased sharply towards the end of the decade. In 1949, the peak year for lobotomies in the United States, 5074 procedures were undertaken and by 1951 over 18608 individuals had been lobotomised in the United States.^[38]

[edit] Prevalence

Quantitatively, most lobotomy procedures were done in the United States, where approximately 40,000 persons were lobotomized. In Great Britain lobotomies were performed on 17,000 people, and the three Scandinavian countries had a combined figure of approximately 9,300 lobotomies.^[39] Scandinavian hospitals lobotomized 2.5 times as many people per capita as hospitals in the United States.^[40] Sweden lobotomized at least 4,500 people between 1944 and 1966, mainly women. This figure includes young children.^[41]

[edit] Indications for lobotomy: medical literature

According to the Psychiatric Dictionary^[42] published in 1970:

Prefrontal lobotomy is of value in the following disorders, listed in a descending scale of good results: affective disorders, obsessive-compulsive states, chronic anxiety states and other non-schizophrenic conditions, paranoid schizophrenia, undetermined or mixed type of schizophrenia, catatonic schizophrenia, and hebephrenic and simple schizophrenia. Good results are obtained in about 40 per cent of cases, fair results in some 35 per cent and poor results in 25 per cent are thereabouts. The mortality rate probably does not exceed 3 per cent. Greatest improvement is seen in patients whose premorbid personalities were 'normal', cyclothymic, or obsessive compulsive; in patients with superior intelligence and good education; in psychoses with sudden onset and a clinical picture of affective symptoms of depression or anxiety, and with behaviouristic changes such as refusal of food, overactivity, and delusional ideas of a paranoid nature.^[43]

Prefrontal lobotomy has also been used successfully to control pain secondary to organic lesions. In this case, the tendency has been to employ unilateral lobotomy, because of the evidence that a lobotomy extensive enough to reduce psychotic symptoms is not required to control pain.^[44]

[edit] Effects of lobotomy: medical literature

According to the Psychiatric Dictionary^[45] published in 1970 prefrontal lobotomy reduces:

anxiety feelings and introspective activities; and feelings of inadequacy and self-consciousness are thereby lessened. Lobotomy reduces the emotional tension associated with hallucinations and does away with the catatonic state. Because nearly all psychosurgical procedures have undesirable side effects, they are ordinarily resorted to only after all other methods have failed. The less disorganized the personality of the patient, the more obvious are post-operative side effects. ...^[46]

Convulsive seizures are reported as sequelae of prefrontal lobotomy in 5 to 10 per cent of all cases. Such seizures are ordinarily well controlled with the usual anti-convulsive drugs. Post-operative blunting of the personality, apathy, and irresponsibility are the rule rather than the exception. Other side effects include distractibility, childishness, facetiousness, lack of tact or discipline, and post-operative incontinence.^[47]

[edit] Criticism of lobotomy

As early as 1944 an author in the Journal of Nervous and Mental Disease remarked that "The history of prefrontal lobotomy has been brief and stormy. Its course has been dotted with both violent opposition and with slavish, unquestioning acceptance." Beginning in 1947 Swedish psychiatrist Snorre Wohlfahrt evaluated early trials, reporting lobotomy to be "distinctly hazardous to leucotomize schizophrenics," "still too imperfect to enable us, with its aid, to venture on a general offensive against chronic cases of mental disorder," and that "Psychosurgery has as yet failed to discover its precise indications and contraindications and the methods must unfortunately still be regarded as rather crude and hazardous in many respects."^[41] In 1948 Norbert Wiener, the author of Cybernetics, said: "...prefrontal lobotomy ...has recently been having a certain vogue, probably not unconnected with the fact that it makes the custodial care of many patients easier. Let me remark in passing that killing them makes their custodial care still easier."^[48]

Concerns about lobotomy steadily grew. The USSR banned the procedure in 1950.^[49] Doctors in the Soviet Union concluded that the procedure was "contrary to the principles of humanity" and that it turned "an insane person into an idiot."^[50] Numerous countries subsequently banned the procedure, including Yugoslavia, Germany and Japan, as did several U.S. states. Lobotomy continued to be legally practiced in controlled and regulated U.S. centers and in Finland, Sweden, Norway (2,005 known cases^[51]), the United Kingdom, Spain, India, Belgium and the Netherlands.

In 1977 the U.S. Congress created a National Committee for the Protection of Human Subjects of Biomedical and Behavioral Research to investigate allegations that psychosurgery—including lobotomy techniques—was used to control minorities and restrain individual rights. It also investigated the after-effects of surgery. The committee concluded that some extremely limited and properly performed psychosurgery could have positive effects.

By the early 1970s the practice had generally ceased, but some countries continued small-scale operations through the late 1980s. According to a report by the International Graphoanalysis Society (IGAS), between 1980 and 1986 there were 70 lobotomies performed in Belgium, 32 in France, 15 per year in the United Kingdom and several cases performed for the Massachusetts General Hospital in Boston.^[52]

[edit] Notable cases (and an oft-cited non-case)

• Rosemary Kennedy, sister of President John F. Kennedy, underwent a lobotomy at age of 23 which left her permanently incapacitated.
• Howard Dully wrote a memoir of his late-life discovery that he had been lobotomized at age 12.
• New Zealand author and poet Janet Frame received a literary award the day before a scheduled lobotomy was to take place, and it was never performed.
• French Canadian singer Alys Robi underwent a lobotomy and later resumed singing professionally.
• Swedish modernist painter Sigrid Hjertén died following a lobotomy in 1948.
• Playwright Tennessee Williams's older sister Rose received a lobotomy which left her incapacitated for life; the episode is said to have inspired characters and motifs in certain of his works.
• It is often said that when an iron rod was accidentally driven through the head of Phineas Gage in 1848, this constituted an "accidental lobotomy," or that this event somehow inspired the development of surgical lobotomy a century later. According to Gage's biographer, careful inquiry turns up no such link.^[53][54]

[edit] Literary and cinematic portrayals

Lobotomies have been featured in several literary and cinematic presentations that both reflected society's attitude towards the procedure and, at times, changed it. The 1946 novel All the King's Men by Robert Penn Warren described a lobotomy, saying it "would have made a Comanche brave look like a tyro [novice] with a scalping knife." The surgeon is portrayed as a repressed man who couldn't change others with love but instead resorted to "high-grade carpentry work."^[55] In Tennessee Williams's 1958 play, Suddenly, Last Summer, the protagonist is threatened with a lobotomy to stop her from telling the truth about her cousin Sebastian.^[56] The surgeon says, "I can't guarantee that a lobotomy would stop her babbling." Her aunt responds, "That may be, maybe not, but after the operation who would believe her, Doctor?"^[57]

A damning portrayal of the procedure is found in Ken Kesey's 1962 novel One Flew Over the Cuckoo's Nest and its 1975 movie adaptation. Several patients in the mental ward receive lobotomies in order to discipline or calm them. The operation is described as brutal and abusive, a "frontal-lobe castration." The book's narrator, Chief Bromden, is shocked: "There's nothin' in the face. Just like one of those store dummies." One patient's surgery changes him from an acute to a chronic mental condition. "You can see by his eyes how they burned him out over there; his eyes are all smoked up and gray and deserted inside."^[55]

Other sources include Sylvia Plath's 1963 novel The Bell Jar, in which the protagonist, Esther, reacts with horror to the "perpetual marble calm" of a lobotomized young woman named Valerie.^[55] Elliott Baker's 1964 novel and 1966 film version, A Fine Madness, portrays the dehumanizing lobotomy of a womanizing, quarrelsome poet who, in the end, is just as aggressive as ever. The surgeon is depicted as an inhumane crackpot.^[58] The 1982 biopic Frances includes a disturbing scene showing actress Frances Farmer undergoing transorbital lobotomy. The claim^[59] that a lobotomy was performed on Farmer (and that Freeman performed it) has been criticized as having little or no evidence supporting it.^[60][61]

[edit] See also

• Bioethics and Medical ethics
• Frontal lobe disorder
• Frontal lobe injury

[edit] Notes

[edit] References

• Acharya, Hernish J. (2004). The Rise and Fall of Frontal Leucotomy. In Whitelaw, W.A. The Proceedings of the 13th Annual History of Medicine Days. Calgary: pp. 32-41.

• Berrios, G.E. (1997). The Origins of Psychosurgery: Shaw, Burckhardt and Moniz. History of Psychiatry. 8 (1): pp. 61-81.

• Braslow, Joel T. (1997). Mental Ills and Bodily Cures: Psychiatric Treatment in the First Half of the Twentieth Century. University of California. ISBN 0520205472

• Brown, Edward M. (2000). Why Wagner-Jauregg won the Nobel Prize for discovering malaria therapy for General Paresis of the Insane. History of Psychiatry. 11 (4): pp. 371-382

• Doby, T. (1992). Cerebral Angiography and Egas Moniz.American Journal of Roentgenology. 359 (2): p. 364.

• Dully, Howard. (2005). 'My Lobotomy': Howard Dully's Journey. All Things Considered. NPR. Retrieved 2009-11-28.

• El-Hai, Jack (2005). The Lobotomist. Wiley. ISBN 0471232920.

• Fleming, G.W.T.H. (1942). Some preliminary remarks on prefrontal leucotomy. Journal of Mental Science. 88 (371): pp. 282-284.

• Fleming, G.W.T.H. and Phillips, D.G. (1949). Transorbital Leucotomy. Journal of Mental Science. 95 (398): pp. 197-202.

• Freeman, Walter and Watts, James W. (1944). Psychosurgery: An Evaluation of Two Hundred Cases over Seven Years. Journal of Mental Science. 90 (379): pp. 532-537.

• Hoenig, J. (1995). Schizophrenia. In Berrios, German and Porter, Roy (Eds.), A History of Clinical Psychiatry: The Origin and History of Psychiatric Disorders. Athlone. ISBN 0485240114

• Jansson, Bengt (1998-10-29). "Controversial Psychosurgery Resulted in a Nobel Prize". Nobelprize.org. Nobel Web AB: Retrieved 2008-03-30

• Kotowicz, Zbigniew (2005). Gottlieb Burckhardt and Egas Moniz - Two Beginnings of Psychosugery. Gesnerus. 62 (1/2): pp. 77-101.

• Manjila, S., Rengachary, S., Xavier, A. R., Parker, B. and Guthikonda, M. (2008). Modern psychosurgery before Egas Moniz: a tribute to Gottlieb Burckhardt Neurosurgery Focus. 25 (1): pp. 1-4.

• Meduna, L.J. (1985). Autobiography of L.J. Meduna. Convulsive Therapy. 1 (1): pp. 43-57.

• Moniz, Egas (1937). Prefrontal Leucotomy in the Treatment of Mental Disorders. Reproduced in American Psychiatric Association, Sesquicentennial Anniversary 1844-1944. American Psychiatric Publishing: p. 237. Retrieved 2009-11-28.

• Ogren K., Sandlund, M. (2005). Psychosurgery in Sweden 1944–1964. Journal of the History of the Neurosciences. 14(4):353-67 PMID 16338693

• Porter, Roy (1999). The Greatest Benefit to Mankind: A Medical History of Humanity from Antiquity to the Present. Fontana Press. ISBN 0006374549

• Приказ МЗ (1951). Невропатология и психиатрия. (20) 1: 17-18.

• Shorter, Edward (1997). A History of Psychiatry: From the Era of the Asylum to the Age of Prozac. Wiley. ISBN 0471245313

• Stone, James L. (2001). Gottlieb Burckhardt - The Pioneer of Psychosurgery. Journal of the History of the Neurosciences. 10 (1): pp. 79-92.

• Wiener, Norbert (1948). Cybernetics. The MIT Press. ISBN 026273009X

[edit] External links

Look up lobotomy in Wiktionary, the free dictionary.

• Portrayal of Lobotomy in the Popular Press: 1935-1960
• My Lobotomy Radio story: Interview with Sallie Ellen Ionesco Lobotomised in 1946
• Psychosurgery.org: Remembering the Tragedy of Lobotomy
• Mental Cruelty: Sunday Times article on lobotomy and contemporary psychosurgery
• Lobotomy's back: Discover article on cingulotomy
• 'My Lobotomy': Howard Dully's Journey. NPR Radio Documentary
• A Qualified Defence of 'Then': QJM