| Name | Country | Gender | Birth | Death | Height | Peak Weight | Peak BMI | Comments |
| Jon Brower Minnoch[1] | USA | M | 1941 | 1983 | 1.85 m (6.1 ft) | 636 kg (1,400 lb; 100.2 st) | 186 kg/m² | His weight loss of approximately 419 kg (920 lb; 66.0 st) is the largest ever documented.[citation needed] |
| Manuel Uribe[2] | Mexico | M | 1965 | | | 597 kg (1,320 lb; 94.0 st) | | After worldwide media attention in January 2006, with help from doctors and nutritionists he lost over 225 kg (500 lb; 35.4 st) over a two year period. |
| Carol Yager[3] | USA | F | 1960 | 1994 | 1.70 m (5.6 ft) | 544 Over 545 kg (1,200 lb; 85.8 st) | 188 kg/m² | Peak weight of 727 kg (1,600 lb; 114.5 st) not confirmed. Documented weight loss of 236 kg (520 lb; 37.2 st) in three months by natural means: a 5,000 kJ (1,200 kcal) per day diet. Weight at death was 545 kg (1,200 lb; 85.8 st). |
| Walter Hudson[4] | USA | M | 1944 | 1991 | | 544 kg (1,200 lb; 85.7 st) | | |
| Michael Hebranko | USA | M | 1953 | | | 500 Over 500 kg (1,100 lb; 79 st) | | In 1990 he was recorded in the Guinness Book of World Records for the highest recorded weight loss due to dieting[5] |
| Patrick Deuel | USA | M | 1962 | | 1.70 m (5.6 ft) | 486 kg (1,070 lb; 76.5 st) | 168 kg/m² | |
| Robert Earl Hughes | USA | M | 1926 | 1958 | | 485 kg (1,070 lb; 76.4 st) | | |
| Rosalie Bradford | USA | F | 1943 | 2006 | 1.69 m (5.5 ft) | 544 kg (1,200 lb; 85.7 st) | 190 kg/m² | Holds the Guinness World Record for most weight lost by a woman, 917 lb |
| Kenneth Brumley | USA | M | 1968 | | | 469 kg (1,030 lb; 73.9 st)[6] | | |
| Mills Darden | USA | M | 1799 | 1857 | 2.3 m (7.5 ft) | 463 kg (1,020 lb; 72.9 st) | 87.5 kg/m² | |