Notable persons who were born, grew up in or established their fame in Regina, Saskatchewan:

• Red Berenson, Team Canada 1972
• Dick Assman, gas station attendant facetiously given fame on the David Letterman television show
• Sarah Binks, fictional character created by Paul Hiebert, in whose gently satirical biography Regina figures as the rustic's metropolis
• Robert Boyer (artist), known as Bob Boyer, visual artist, elder, university professor
• Beverley Breuer, actor whose credits include Scary Movie 4.
• Garth Butcher, NHL player
• Murray Crewe, principal bass trombonist, Pittsburgh Symphony Orchestra^{[citation needed]}
• Charlie David, actor
• Robert Dirk, former NHLer
• Shirley Douglas, actor, daughter of T.C. Douglas; mother of Kiefer Sutherland
• T.C. Douglas, CCF premier 1944–1961 and later leader of the federal New Democratic Party
• Duke Dukowski, former NHLer
• Into Eternity, a Progressive metal band
• Joe Fafard, sculptor and artist
• Ryan Getzlaf, NHL player
• Dirk Graham, NHL player
• Scott Hartnell, NHL player
• Brad Herauf, ECHL, AHL player
• Jamie Heward, NHL player
• Roger Ing, artist
• Dick Irvin, Jr., Hockey Night in Canada broadcaster
• Colin James, a 2 time Juno award winning blues-rock musician
• Connie Kaldor, singer
• Chris Kunitz, NHL player
• Donald M. Kendrick, Calgary native, choral conductor and teacher at the University of Saskatchewan, Regina Campus, in the 1970s
• Sarah Lind, actor
• Steve Nash, NBA all-star
• Garth Murray, NHL player
• Zarqa Nawaz, creator of the CBC sitcom Little Mosque on the Prairie
• Leslie Nielsen, actor whose credits include Airplane!, Naked Gun and Scary Movie 4.
• Erik Nielsen, federal politician, former deputy prime minister
• Michael Peers, Archbishop of Qu'Appelle; Primate of the Anglican Church of Canada1986-2004.
• Jason Plumb, popular musician formerly with the Waltons
• Logan Pyett, AHL player (In the Detroit Red Wings organization) and member of gold-medal winning Team Canada's in 2005-2006 (U18 Junior World Cup) and 2007-2008 (World Junior Championship).
• Erika Ritter, playwright and broadcaster
• Jack Semple, noted blues guitarist
• Kenny Shields, Juno award winning musician with locally based band Streetheart in the 80's^{[citation needed]}
• Shiloh, singer
• Mike Sillinger, NHL player
• Mick McGeough, NHL referee
• Stephen Surjik, television and motion picture director whose credits include The Kids in the Hall and Wayne's World 2.
• Dione Taylor, noted jazz singer
• John Vernon, actor in several movies and Television shows. "Animal House", "Wojeck" to name a couple.
• Richard Walker, President and CEO of the 40th International WorldSkills Competition in Calgary in 2009
• Murray Westgate (b. 1918), actor
• Karl Schubach, Vocalist of metalcore band Misery Signals