Guest stars are listed in chronological order by episode. Each episode's guest stars are listed in alphabetical order. People who guest star in multiple episodes are listed for each separate episode they appear in; as such if the play multiple roles in one episode these will be listed together.
There are several non-regular voices who make appearances but are credited as "also starring" and not guest voices. These voices are not mentioned here. Similarly, Marcia Wallace has appeared frequently and has been credited as a guest star, but is not included here.
| Ep. no. and title | Guest star | Role(s) |
| 0103 - "Homer's Odyssey" | McMurray, SamSam McMurray | Worker |
| 0106 - "Moaning Lisa" | Taylor, RonRon Taylor | Bleeding Gums Murphy |
| 0107 - "The Call of the Simpsons" | Brooks, AlbertAlbert Brooks[A] | Cowboy Bob |
| 0109 - "Life on the Fast Lane" | Brooks, Albert Albert Brooks | Jacques |
| 0110 - "Homer's Night Out" | McMurray, Sam Sam McMurray | Gulliver Dark |
| 0112 - "Krusty Gets Busted" | Grammer, KelseyKelsey Grammer | Sideshow Bob |
| 0113 - "Some Enchanted Evening" | Foray, JuneJune Foray | Babysitter service receptionist |
| 0113 - "Some Enchanted Evening" | Marshall, PennyPenny Marshall | Ms. Lucille Botz |
| 0113 - "Some Enchanted Evening" | Willson, PaulPaul Willson | Florist |
| 0202 - "Simpson and Delilah" | Fierstein, HarveyHarvey Fierstein | Karl |
| 0203 - "Treehouse of Horror" | Jones, James EarlJames Earl Jones | Removal man
Serak the Preparer
Narrator |
| 0205 - "Dancin' Homer" | Bennett, TonyTony Bennett | Himself |
| 0205 - "Dancin' Homer" | Coley, Daryl L. Daryl L. Coley | Bleeding Gums Murphy |
| 0205 - "Dancin' Homer" | Levine, KenKen Levine | Dan Horde |
| 0205 - "Dancin' Homer" | Poston, TomTom Poston | Capitol City Goofball |
| 0207 - "Bart vs. Thanksgiving" | Berg, GregGreg Berg | Rory |
| 0209 - "Itchy & Scratchy & Marge" | Rocco, AlexAlex Rocco | Roger Meyers Jr. |
| 0210 - "Bart Gets Hit by a Car" | Hartman, PhilPhil Hartman | Lionel Hutz
Heaven |
| 0211 - "One Fish, Two Fish, Blowfish, Blue Fish" | King, LarryLarry King | Himself |
| 0211 - "One Fish, Two Fish, Blowfish, Blue Fish" | Miyashima, JoeyJoey Miyashima | Toshiro |
| 0211 - "One Fish, Two Fish, Blowfish, Blue Fish" | Shimono, SabSab Shimono | Master Sushi Chef |
| 0211 - "One Fish, Two Fish, Blowfish, Blue Fish" | Takei, GeorgeGeorge Takei | Akira |
| 0211 - "One Fish, Two Fish, Blowfish, Blue Fish" | Tanaka, Diane Diane Tanaka | Hostess |
| 0212 - "The Way We Was" | Lovitz, JonJon Lovitz | Artie Ziff |
| 0213 - "Homer vs. Lisa and the 8th Commandment" | Hartman, Phil Phil Hartman | Troy McClure
Moses
Cable guy |
| 0215 - "Oh Brother, Where Art Thou?" | DeVito, DannyDanny DeVito | Herbert Powell |
| 0216 - "Bart's Dog Gets an F" | Ullman, TraceyTracey Ullman | Emily Winthropp |
| 0216 - "Bart's Dog Gets an F" | Welker, FrankFrank Welker | Santa's Little Helper
Additional dog voices |
| 0217 - "Old Money" | Hartman, Phil Phil Hartman | Lionel Hutz
Plato |
| 0217 - "Old Money" | Meadows, AudreyAudrey Meadows | Bea Simmons |
| 0218 - "Brush with Greatness | Lovitz, Jon Jon Lovitz | Professor Lombardo |
| 0218 - "Brush with Greatness" | Starr, RingoRingo Starr | Himself |
| 0219 - "Lisa's Substitute" | Hoffman, DustinDustin Hoffman[B] | Mr. Bergstrom |
| 0221 - "Three Men and a Comic Book | Leachman, ClorisCloris Leachman | Mrs. Glick |
| 0221 - "Three Men and a Comic Book" | Stern, DanielDaniel Stern | Narrator |
| 0301 - "Stark Raving Dad" | Jackson, MichaelMichael Jackson[C] | Leon Kompowsky |
| 0301 - "Stark Raving Dad" | Lennon, KippKipp Lennon | Leon Kompowsky's singing voice[2] |
| 0304 - "Bart the Murderer" | Harris, Neil PatrickNeil Patrick Harris | Himself playing Bart Simpson |
| 0304 - "Bart the Murderer" | Hartman, Phil Phil Hartman | Lionel Hutz
Troy McClure |
| 0304 - "Bart the Murderer" | Mantegna, JoeJoe Mantegna | Fat Tony |
| 0305 - "Homer Defined" | Hearn, ChickChick Hearn | Announcer |
| 0305 - "Homer Defined" | Johnson, MagicMagic Johnson | Himself |
| 0305 - "Homer Defined" | Lovitz, Jon Jon Lovitz | Aristotle Amadopolis |
| 0306 - "Like Father, Like Clown | Mason, JackieJackie Mason | Rabbi Krustofski |
| 0308 - "Lisa's Pony" | Welker, Frank Frank Welker | Princess |
| 0309 - "Saturdays of Thunder" | Hartman, Phil Phil Hartman | Troy McClure |
| 0310 - "Flaming Moe's" | Aerosmith Aerosmith[D] | Themselves |
| 0310 - "Flaming Moe's" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0311 - "Burns Verkaufen der Kraftwerk" | Hartman, Phil Phil Hartman | Horst
Stockbroker |
| 0313 - "Radio Bart" | Sting | Himself |
| 0314 - "Lisa the Greek" | Hartman, Phil Phil Hartman | Troy McClure
Smooth Jimmy Apollo |
| 0315 - "Homer Alone" | Hartman, Phil Phil Hartman | Troy McClure |
| 0317 - "Homer at the Bat" | Boggs, WadeWade Boggs | Himself |
| 0317 - "Homer at the Bat" | Canseco, JoséJosé Canseco | Himself |
| 0317 - "Homer at the Bat" | Cashman, TerryTerry Cashman | Sings "Talkin' Softball" |
| 0317 - "Homer at the Bat" | Clemens, RogerRoger Clemens | Himself |
| 0317 - "Homer at the Bat" | Griffey, Jr., KenKen Griffey, Jr. | Himself |
| 0317 - "Homer at the Bat" | Mattingly, DonDon Mattingly | Himself |
| 0317 - "Homer at the Bat" | Sax, SteveSteve Sax | Himself |
| 0317 - "Homer at the Bat" | Scioscia, MikeMike Scioscia | Himself |
| 0317 - "Homer at the Bat" | Smith, OzzieOzzie Smith | Himself |
| 0317 - "Homer at the Bat" | Strawberry, DarrylDarryl Strawberry | Himself |
| 0318 - "Separate Vocations" | Allen, SteveSteve Allen | Electronically altered voice of Bart |
| 0319 - "Dog of Death" | Welker, Frank Frank Welker | Santa's Little Helper |
| 0320 - "Colonel Homer" | D'Angelo, BeverlyBeverly D'Angelo | Lurleen Lumpkin |
| 0321 - "Black Widower" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 0322 - "The Otto Show" | Guest, ChristopherChristopher Guest | Nigel Tufnel |
| 0322 - "The Otto Show" | McKean, MichaelMichael McKean | David St. Hubbins |
| 0323 - "Bart's Friend Falls in Love" | Hartman, Phil Phil Hartman | Troy McClure |
| 0323 - "Bart's Friend Falls in Love" | Robertson, KimmyKimmy Robertson | Samantha Stanky |
| 0324 - "Brother, Can You Spare Two Dimes?" | DeVito, Danny Danny DeVito | Herbert Powell |
| 0324 - "Brother, Can You Spare Two Dimes?" | Frazier, JoeJoe Frazier | Himself |
| 0401 - "A Streetcar Named Marge" | Hartman, Phil Phil Hartman | Troy McClure
Lionel Hutz |
| 0401 - "A Streetcar Named Marge" | Lovitz, Jon Jon Lovitz | Llewellyn Sinclair
Ms. Sinclair |
| 0403 - "Lisa the Beauty Queen | Hope, BobBob Hope | Himself |
| 0407 - "Marge Gets a Job" | Hartman, Phil Phil Hartman | Troy McClure
Lionel Hutz |
| 0407 - "Marge Gets a Job" | Jones, TomTom Jones | Himself |
| 0408 - "New Kid on the Block" | Gilbert, SaraSara Gilbert | Laura Powers |
| 0408 - "New Kid on the Block" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0408 - "New Kid on the Block" | Reed, PamelaPamela Reed | Ruth Powers |
| 0409 - "Mr. Plow" | Hartman, Phil Phil Hartman | Troy McClure |
| 0409 - "Mr. Plow" | Ronstadt, LindaLinda Ronstadt | Herself |
| 0409 - "Mr. Plow" | West, AdamAdam West | Himself |
| 0410 - "Lisa's First Word" | Taylor, ElizabethElizabeth Taylor | Maggie Simpson |
| 0412 - "Marge vs. the Monorail" | Hartman, Phil Phil Hartman | Lyle Lanley |
| 0412 - "Marge vs the Monorail" | Nimoy, LeonardLeonard Nimoy | Himself |
| 0413 - "Selma's Choice" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0414 - "Brother from the Same Planet" | Hartman, Phil Phil Hartman | Tom
Mr. Muntz |
| 0416 - "Duffless" | Hartman, Phil Phil Hartman | Troy McClure
Lionel Hutz |
| 0417 - "Last Exit to Springfield" | Brothers, JoyceJoyce Brothers | Herself |
| 0419 - "The Front" | Shields, BrookeBrooke Shields | Herself |
| 0420 - "Whacking Day" | White, BarryBarry White | Himself |
| 0421 - "Marge in Chains" | Crosby, DavidDavid Crosby | Himself |
| 0421 - "Marge in Chains" | Hartman, Phil Phil Hartman | Troy McClure
Lionel Hutz |
| 0422 - "Krusty Gets Kancelled" | Carson, JohnnyJohnny Carson | Himself |
| 0422 - "Krusty Gets Kancelled" | Hefner, HughHugh Hefner | Himself |
| 0422 - "Krusty Gets Kancelled" | Midler, BetteBette Midler | Herself |
| 0422 - "Krusty Gets Kancelled" | Perry, LukeLuke Perry | Himself |
| 0422 - "Krusty Gets Kancelled" | Red Hot Chili Peppers Red Hot Chili Peppers[E] | Themselves |
| 0422 - "Krusty Gets Kancelled" | Taylor, Elizabeth Elizabeth Taylor | Herself |
| 0422 - "Krusty Gets Kancelled" | White, Barry Barry White | Himself |
| 0501 - "Homer's Barbershop Quartet" | Crosby, David David Crosby | Himself |
| 0501 - "Homer's Barbershop Quartet" | The Dapper Dans The Dapper Dans[F] | The singing voices of the Be Sharps |
| 0501 - "Homer's Barbershop Quartet" | Harrison, GeorgeGeorge Harrison | Himself |
| 0502 - "Cape Feare" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 0504 - "Rosebud" | The Ramones The Ramones[G] | Themselves |
| 0505 - "Treehouse of Horror IV" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0505 - "Treehouse of Horror IV" | Welker, Frank Frank Welker | Gremlin |
| 0506 - "Marge on the Lam" | Fenneman, GeorgeGeorge Fenneman | Narrator |
| 0506 - "Marge on the Lam" | Hartman, Phil Phil Hartman | Troy McClure
Lionel Hutz |
| 0506 - "Marge on the Lam" | Reed, Pamela Pamela Reed | Ruth Powers |
| 0507 - "Bart's Inner Child" | Brooks, Albert Albert Brooks | Brad Goodman |
| 0507 - "Bart's Inner Child" | Brown, JamesJames Brown | Himself |
| 0507 - "Bart's Inner Child" | Hartman, Phil Phil Hartman | Troy McClure |
| 0508 - "Boy-Scoutz n the Hood" | Borgnine, ErnestErnest Borgnine | Himself |
| 0509 - "The Last Temptation of Homer" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0509 - "The Last Temptation of Homer" | Klemperer, WernerWerner Klemperer | Colonel Klink |
| 0509 - "The Last Temptation of Homer" | Pfeiffer, MichelleMichelle Pfeiffer | Mindy Simmons |
0510 - "$pringfield (Or, How I Learned to
Stop Worrying and Love Legalized Gambling)" | Cooney, GerryGerry Cooney | Himself |
0510 - "$pringfield (Or, How I Learned to
Stop Worrying and Love Legalized Gambling)" | Goulet, RobertRobert Goulet | Himself |
| 0511 - "Homer the Vigilante" | Neill, SamSam Neill | Molloy |
| 0512 - "Bart Gets Famous" | O'Brien, ConanConan O'Brien | Himself |
| 0513 - "Homer and Apu" | Woods, JamesJames Woods | Himself |
| 0514 - "Lisa vs. Malibu Stacy | Turner, KathleenKathleen Turner | Stacy Lovell |
| 0515 - "Deep Space Homer" | Aldrin, BuzzBuzz Aldrin | Himself |
| 0515 - "Deep Space Homer" | Taylor, JamesJames Taylor | Himself |
| 0517 - "Bart Gets an Elephant" | Welker, Frank Frank Welker | Stampy |
| 0518 - "Burns' Heir" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0519 - "Sweet Seymour Skinner's Baadasssss Song" | Welker, Frank Frank Welker | Santa's Little Helper |
| 0520 - "The Boy Who Knew Too Much" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0521 - "Lady Bouvier's Lover" | Hartman, Phil Phil Hartman | Troy McClure |
| 0522 - "Secrets of a Successful Marriage" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0602 - "Lisa's Rival" | Ryder, WinonaWinona Ryder | Allison Taylor |
| 0605 - "Sideshow Bob Roberts" | Corden, HenryHenry Corden | Fred Flintstone |
| 0605 - "Sideshow Bob Roberts" | Demento, Dr.Dr. Demento | Himself |
| 0605 - "Sideshow Bob Roberts" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 0605 - "Sideshow Bob Roberts" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0605 - "Sideshow Bob Roberts" | King, Larry Larry King | Himself |
| 0606 - "Treehouse of Horror" | Jones, James Earl James Earl Jones | Alternate universe Maggie |
| 0607 - "Bart's Girlfriend" | Streep, MerylMeryl Streep | Jessica Lovejoy |
| 0609 - "Homer Badman" | Franz, DennisDennis Franz | Himself playing Homer |
| 0610 - "Grampa vs. Sexual Inadequacy" | Hartman, Phil Phil Hartman | Troy McClure |
| 0611 - "Fear of Flying" | Bancroft, AnneAnne Bancroft | Dr. Zweig |
| 0611 - "Fear of Flying" | Danson, TedTed Danson | Sam Malone |
| 0611 - "Fear of Flying" | Harrelson, WoodyWoody Harrelson | Woody Boyd |
| 0611 - "Fear of Flying" | Ratzenberger, JohnJohn Ratzenberger | Cliff Clavin |
| 0611 - "Fear of Flying" | Perlman, RheaRhea Perlman | Carla Tortelli |
| 0611 - "Fear of Flying" | Wendt, GeorgeGeorge Wendt | Norm Peterson |
| 0612 - "Homer the Great" | Stewart, PatrickPatrick Stewart | Number One |
| 0615 - "Homie the Clown" | Cavett, DickDick Cavett | Himself |
| 0615 - "Homie the Clown" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 0615 - Homie the Clown" | Unitas, JohnnyJohnny Unitas | Himself |
| 0616 - "Bart vs. Australia" | Hartman, Phil Phil Hartman | Evan Conover |
| 0617 - "Homer vs. Patty and Selma" | Brooks, MelMel Brooks | Himself |
| 0617 - "Homer vs. Patty and Selma" | Sarandon, SusanSusan Sarandon | Ballet teacher |
| 0618 - "A Star is Burns" | Hartman, Phil Phil Hartman | Charlton Heston |
| 0618 - "A Star is Burns" | LaMarche, MauriceMaurice LaMarche | George C. Scott |
| 0618 - "A Star is Burns" | Lovitz, Jon Jon Lovitz | Jay Sherman |
| 0619 - "Lisa's Wedding" | Hartman, Phil Phil Hartman | Troy McClure |
| 0619 - "Lisa's Wedding" | Patinkin, MandyMandy Patinkin | Hugh Parkfield |
| 0620 - "Two Dozen and One Greyhounds" | Welker, Frank Frank Welker | Various dogs |
| 0622 - "'Round Springfield" | Allen, Steve Steve Allen | Himself |
| 0622 - "'Round Springfield" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0622 - "'Round Springfield" | Taylor, Ron Ron Taylor | Bleeding Gums Murphy |
| 0623 - "The Springfield Connection" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0624/0701 - "Who Shot Mr. Burns?" | Puente, TitoTito Puente | Himself |
| 0702 - "Radioactive Man" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0702 - "Radioactive Man" | Rooney, MickeyMickey Rooney | Himself |
| 0703 - "Home Sweet Homediddly-Dum-Doodily" | Kenley, JoanJoan Kenley | Telephone voice |
| 0704 - "Lisa the Vegetarian" | Hartman, Phil Phil Hartman | Troy McClure |
| 0704 - "Lisa the Vegetarian" | McCartney, LindaLinda McCartney | Herself |
| 0704 - "Lisa the Vegetarian" | McCartney, PaulPaul McCartney | Himself |
| 0706 - "Treehouse of Horror VI" | Anka, PaulPaul Anka | Himself |
| 0707 - "King-Size Homer" | Kenley, Joan Joan Kenley | Telephone voice |
| 0708 - "Mother Simpson" | Close, GlennGlenn Close | Mona Simpson |
| 0708 - "Mother Simpson" | Morgan, HarryHarry Morgan | Bill Gannon |
| 0709 - "Sideshow Bob's Last Gleaming" | Ermey, R. LeeR. Lee Ermey | Colonel Leslie Hapablap |
| 0709 - "Sideshow Bob's Last Gleaming" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 0710 - "The Simpsons 138th Episode Spectacular" | Hartman, Phil Phil Hartman | Troy McClure |
| 0711 - "Marge Be Not Proud" | Hartman, Phil Phil Hartman | Troy McClure |
| 0711 - "Marge Be Not Proud" | Tierney, LawrenceLawrence Tierney | Don Brodka |
| 0714 - "Scenes from the Class Struggle in Springfield" | Kite, TomTom Kite | Himself |
| 0715 - "Bart the Fink" | Hartman, Phil Phil Hartman | Troy McClure |
| 0715 - "Bart the Fink" | Newhart, BobBob Newhart | Himself |
| 0716 - "Lisa the Iconoclast" | Hartman, Phil Phil Hartman | Troy McClure |
| 0716 - "Lisa the Iconoclast" | Sutherland, DonaldDonald Sutherland | Hollis Hurlbut |
| 0718 - "The Day the Violence Died" | Douglas, KirkKirk Douglas | Chester J. Lampwick |
| 0718 - "The Day the Violence Died" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0718 - "The Day the Violence Died" | Rocco, Alex Alex Rocco | Roger Meyers, Jr. |
| 0718 - "The Day the Violence Died" | Sheldon, JackJack Sheldon | Amendment |
| 0718 - "The Day the Violence Died" | Somers, SuzanneSuzanne Somers | Herself |
| 0719 - "A Fish Called Selma" | Goldblum, JeffJeff Goldblum | MacArthur Park |
| 0719 - "A Fish Called Selma" | Hartman, Phil Phil Hartman | Troy McClure |
| 0720 - "Bart on the Road" | Lau, Jim Jim Lau | Hong Kong doctor |
| 0721 - "22 Short Films About Springfield" | Hartman, Phil Phil Hartman | Lionel Hutz
Hospital chairman |
| 0723 - "Much Apu About Nothing" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 0724 - "Homerpalooza" | Cypress Hill Cypress Hill[H] | Themselves |
| 0724 - "Homerpalooza" | Frampton, PeterPeter Frampton | Himself |
| 0724 - "Homerpalooza" | The Smashing Pumpkins The Smashing Pumpkins[I] | Themselves |
| 0724 - "Homerpalooza" | Sonic Youth Sonic Youth[J] | Themselves |
| 0725 - "Summer of 4 Ft. 2" | Ricci, ChristinaChristina Ricci | Erin |
| 0801 - "Treehouse of Horror VII" | Hartman, Phil Phil Hartman | Bill Clinton |
| 0802 - "You Only Move Twice" | Brooks, Albert Albert Brooks | Hank Scorpio |
| 0802 - "You Only Move Twice" | Steven, Sally Sally Stevens | Sings "Scorpio" |
| 0803 - "The Homer They Fall" | Buffer, MichaelMichael Buffer | Himself |
| 0803 - "The Homer They Fall" | Winfield, PaulPaul Winfield | Lucius Sweet |
| 0804 - "Burns, Baby Burns" | Dangerfield, RodneyRodney Dangerfield | Larry Burns |
| 0808 - "Hurricane Neddy" | Lovitz, Jon Jon Lovitz | Jay Sherman |
0809 - "El Viaje Misterioso de Nuestro Jomer
(The Mysterious Voyage of Homer)" | Cash, JohnnyJohnny Cash | Coyote |
| 0810 - "The Springfield Files" | Anderson, GillianGillian Anderson | Dana Scully |
| 0810 - "The Springfield Files" | Duchovny, DavidDavid Duchovny | Fox Mulder |
| 0810 - "The Springfield Files" | Nimoy, Leonard Leonard Nimoy | Himself |
| 0811 - "The Twisted World of Marge Simpson" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 0811 - "The Twisted World of Marge Simpson" | Lemmon, JackJack Lemmon | Frank Ormand |
| 0814 - "The Itchy & Scratchy & Poochie Show" | Hartman, Phil Phil Hartman | Troy McClure |
| 0814 - "The Itchy & Scratchy & Poochie Show" | Rocco, Alex Alex Rocco | Roger Meyers Jr. |
| 0815 - "Homer's Phobia" | Waters, JohnJohn Waters | John |
| 0816 - "Brother from Another Series" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 0816 - "Brother from Another Series" | Pierce, David HydeDavid Hyde Pierce | Cecil Terwilliger
Man in the crowd[3] |
| 0818 - "Homer vs. the Eighteenth Amendment" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 0818 - "Homer vs. the Eighteenth Amendment" | Thomas, DaveDave Thomas | Rex Banner |
| 0820 - "The Canine Mutiny" | Welker, Frank Frank Welker | Laddie |
| 0821 - "The Old Man and the Lisa" | Hart, BretBret Hart | Himself |
| 0822 - "In Marge We Trust" | Kumagai, Denice Denice Kumagai | Dancer |
| 0822 - "In Marge We Trust" | Maruyama, KarenKaren Maruyama | Dancer |
| 0822 - "In Marge We Trust" | Shimono, Sab Sab Shimono | Mr. Sparkle
Factory worker |
| 0822 - "In Marge We Trust" | Watanabe, GeddeGedde Watanabe | Factory foreman |
| 0822 - "In Marge We Trust" | Welker, Frank Frank Welker | Baboons |
| 0823 - "Homer's Enemy" | Welker, Frank Frank Welker | Executive Vice President dog |
| 0824 - "The Simpsons Spin-Off Showcase" | Conway, TimTim Conway | Himself |
| 0824 - "The Simpsons Spin-Off Showcase" | Hartman, Phil Phil Hartman | Troy McClure |
| 0824 - "The Simpsons Spin-Off Showcase" | Sartain, GailardGailard Sartain | Charles "Big" Daddy |
| 0825 - "The Secret War of Lisa Simpson" | Dafoe, WillemWillem Dafoe | The Commandant |
| 0901 - "The City of New York vs. Homer Simpson" | Kenley, Joan Joan Kenley | Telephone voice |
| 0902 - "The Principal and the Pauper" | Sheen, MartinMartin Sheen | The real Seymour Skinner |
| 0903 - "Lisa's Sax" | Finkel, FyvushFyvush Finkel | Himself playing Krusty |
| 0906 - "Bart Star" | Firestone, RoyRoy Firestone | Himself |
| 0906 - "Bart Star" | Judge, MikeMike Judge | Hank Hill |
| 0906 - "Bart Star" | Namath, JoeJoe Namath | Himself |
| 0907 - "The Two Mrs. Nahasapeemapetilons" | Hooks, JanJan Hooks | Manjula Nahasapeemapetilon |
| 0907 - "The Two Mrs. Nahasapeemapetilons" | Martin, AndreaAndrea Martin | Apu's mother |
| 0908 - "Lisa the Skeptic" | Gould, Stephen JayStephen Jay Gould | Himself |
| 0908 - "Lisa the Skeptic" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0909 - "Realty Bites" | Hartman, Phil Phil Hartman | Lionel Hutz |
| 0910 - "Miracle on Evergreen Terrace" | Trebek, AlexAlex Trebek | Himself |
| 0912 - "Bart Carny" | Varney, JimJim Varney | Cooter |
| 0914 - "Das Bus" | Hartman, Phil Phil Hartman | Troy McClure |
| 0914 - "Das Bus" | Jones, James Earl James Earl Jones | Narrator |
| 0914 - "Das Bus" | Ong, Jack Jack Ong | Fisherman |
| 0915 - "The Last Temptation of Krust" | Baum, BruceBruce Baum | Himself |
| 0915 - "The Last Temptation of Krust" | Garofalo, JaneaneJaneane Garofalo | Herself |
| 0915 - "The Last Temptation of Krust" | Goldthwait, BobcatBobcat Goldthwait | Himself |
| 0915 - "The Last Temptation of Krust" | Leno, JayJay Leno | Himself |
| 0915 - "The Last Temptation of Krust" | Williams, Jr., HankHank Williams, Jr. | Sings "Canyonero!" |
| 0915 - "The Last Temptation of Krust" | Wright, StevenSteven Wright | Himself |
| 0916 - "Dumbbell Indemnity" | Hunt, HelenHelen Hunt | Renee |
| 0917 - "Lisa the Simpson" | Hartman, Phil Phil Hartman | Troy McClure |
| 0918 - "This Little Wiggy" | Hartman, Phil Phil Hartman | Troy McClure |
| 0919 - "Simpson Tide" | Denver, BobBob Denver | Himself |
| 0919 - "Simpson Tide" | Steiger, RodRod Steiger | Captain Tenille |
| 0920 - "The Trouble with Trillions" | Winfield, Paul Paul Winfield | Lucius Sweet |
| 0922 - "Trash of the Titans" | Martin, SteveSteve Martin | Ray Patterson |
| 0922 - "Trash of the Titans" | McGuinness, PaulPaul McGuinness | Himself[4] |
| 0922 - "Trash of the Titans" | Smith, Susie Susie Smith | Herself[4] |
| 0922 - "Trash of the Titans" | U2 U2[K] | Themselves |
| 0923 - "King of the Hill" | Fraser, BrendanBrendan Fraser | Brad |
| 0923 - "King of the Hill" | Weber, StevenSteven Weber | Neil |
| 1001 - "Lard of the Dance" | Kudrow, LisaLisa Kudrow | Alex Whitney |
| 1002 - "The Wizard of Evergreen Terrace" | Daniels, WilliamWilliam Daniels | KITT |
| 1003 - "Bart the Mother" | Hartman, Phil Phil Hartman | Troy McClure |
| 1004 - "Treehouse of Horror IX" | Englund, RobertRobert Englund | Freddy Krueger |
| 1004 - "Treehouse of Horror IX" | Gifford, Kathie LeeKathie Lee Gifford | Herself |
| 1004 - "Treehouse of Horror IX" | McMahon, EdEd McMahon | Himself |
| 1004 - "Treehouse of Horror IX" | Philbin, RegisRegis Philbin | Himself |
| 1004 - "Treehouse of Horror IX" | Springer, JerryJerry Springer | Himself |
| 1005 - "When You Dish Upon a Star" | Baldwin, AlecAlec Baldwin | Himself |
| 1005 - "When You Dish Upon a Star" | Basinger, KimKim Basinger | Herself |
| 1005 - "When You Dish Upon a Star" | Grazer, BrianBrian Grazer | Himself |
| 1005 - "When You Dish Upon a Star" | Howard, RonRon Howard | Himself |
| 1006 - "D'oh-in in the Wind" | Carlin, GeorgeGeorge Carlin | Munchie |
| 1006 - "D'oh-in in the Wind" | Mull, MartinMartin Mull | Seth |
| 1006 - "D'oh-in in the Wind" | Yo La Tengo Yo La Tengo | Play end credits |
| 1009 - "Mayored to the Mob" | Hamill, MarkMark Hamill | Himself
Leavelle[5] |
| 1009 - "Mayored to the Mob" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1009 - "Mayored to the Mob" | Tufeld, DickDick Tufeld | Lost in Space robot |
| 1010 - "Viva Ned Flanders" | The Moody Blues The Moody Blues[L] | Themselves |
| 1011 - "Wild Barts Can't Be Broken" | Lauper, CyndiCyndi Lauper | Herself |
| 1012 - "Sunday, Cruddy Sunday" | Aikman, TroyTroy Aikman | Himself |
| 1012 - "Sunday, Cruddy Sunday" | Grier, RoseyRosey Grier | Himself |
| 1012 - "Sunday, Cruddy Sunday" | Madden, JohnJohn Madden | Himself |
| 1012 - "Sunday, Cruddy Sunday" | Marino, DanDan Marino | Himself |
| 1012 - "Sunday, Cruddy Sunday" | Murdoch, RupertRupert Murdoch | Himself |
| 1012 - "Sunday, Cruddy Sunday" | Parton, DollyDolly Parton | Herself |
| 1012 - "Sunday, Cruddy Sunday" | Summerall, PatPat Summerall | Himself |
| 1012 - "Sunday, Cruddy Sunday" | Willard, FredFred Willard | Wally Kogen |
| 1013 - "Homer to the Max" | Begley, Jr., EdEd Begley, Jr. | Himself |
| 1014 - "I'm with Cupid" | Hooks, Jan Jan Hooks | Manjula Nahasapeemapetilon |
| 1014 - "I'm with Cupid" | John, EltonElton John | Himself |
| 1015 - "Marge Simpson in: "Screaming Yellow Honkers"" | Kassir, JohnnyJohnny Kassir | Possum |
| 1019 - "Mom and Pop Art" | Johns, JasperJasper Johns | Himself |
| 1019 - "Mom and Pop Art" | Rossellini, IsabellaIsabella Rossellini | Astrid Weller |
| 1020 - "The Old Man and the "C" Student" | LaLanne, JackJack LaLanne | Himself |
| 1020 - "The Old Man and the "C" Student" | NRBQ NRBQ | Sing "Can't Buy Me Love" |
| 1021 - "Monty Can't Buy Me Love" | McKean, Michael Michael McKean | Jerry Rude |
| 1022 - "They Saved Lisa's Brain" | Hawking, StephenStephen Hawking | Himself |
| 1023 - "Thirty Minutes over Tokyo" | Kumagai, Denice Denice Kumagai | Mother |
| 1023 - "Thirty Minutes over Tokyo" | Maruyama, Karen Karen Maruyama | Stewardess |
| 1023 - "Thirty Minutes over Tokyo" | Takei, George George Takei | Wink |
| 1023 - "Thirty Minutes over Tokyo" | Watanabe, Gedde Gedde Watanabe | Waiter
Father
Toilet |
| 1023 - "Thirty Minutes over Tokyo" | Young, KeoneKeone Young | Sumo wrestler |
| 1101 - "Beyond Blunderdome" | Burns, JackJack Burns | Edward Christian |
| 1101 - "Beyond Blunderdome" | Gibson, MelMel Gibson | Himself |
| 1102 - "Brother's Little Helper" | McGwire, MarkMark McGwire | Himself |
| 1103 - "Guess Who's Coming to Criticize Dinner?" | Asner, EdwardEdward Asner | Newspaper editor |
| 1104 - "Treehouse of Horror X" | Arnold, TomTom Arnold | Himself |
| 1104 "Treehouse of Horror X" | Clark, DickDick Clark | Himself |
| 1104 - "Treehouse of Horror X" | Lawless, LucyLucy Lawless | Herself |
| 1104 - "Treehouse of Horror X" | Welker, Frank Frank Welker | Werewolf Flanders |
| 1105 - "E-I-E-I-(Annoyed Grunt)" | The B-52's The B-52's | Sing "Glove Slap" |
| 1105 - "E-I-E-I-(Annoyed Grunt)" | Welker, Frank Frank Welker | Various animals |
| 1106 - "Hello Gutter, Hello Fadder" | Howard, Ron Ron Howard | Himself |
| 1106 - "Hello Gutter, Hello Fadder" | Jillette, PennPenn Jillette | Himself |
| 1106 - "Hello Gutter, Hello Fadder" | O'Brien, PatPat O'Brien | Himself |
| 1106 - "Hello Gutter, Hello Fadder" | O'Dell, NancyNancy O'Dell | Herself |
| 1106 - "Hello Gutter, Hello Fadder" | Teller | Himself |
| 1107 - "Eight Misbehavin'" | Hooks, Jan Jan Hooks | Manjula Nahasapeemapetilon |
| 1107 - "Eight Misbehavin'" | Marshall, GarryGarry Marshall | Larry Kidkill |
| 1107 - "Eight Misbehavin'" | Patrick, ButchButch Patrick | Himself |
| 1108 - "Take My Wife, Sleaze" | Goodman, JohnJohn Goodman | Meathook |
| 1108 - "Take My Wife, Sleaze" | Hooks, Jan Jan Hooks | Manjula Nahasapeemapetilon |
| 1108 - "Take My Wife, Sleaze" | North, JayJay North | Himself |
| 1108 - "Take My Wife, Sleaze" | NRBQ | Perform various songs |
| 1108 - "Take My Wife, Sleaze" | Winkler, HenryHenry Winkler | Ramrod |
| 1109 - "Grift of the Magi" | Clemons, ClarenceClarence Clemons | Narrator |
| 1109 - "Grift of the Magi" | Coleman, GaryGary Coleman | Himself |
| 1109 - "Grift of the Magi" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1109 - "Grift of the Magi" | Robbins, TimTim Robbins | Jim Hope |
| 1110 - "Little Big Mom" | Edwards, ElwoodElwood Edwards | Virtual doctor |
| 1111 - "Faith Off" | Cheadle, DonDon Cheadle | Brother Faith |
| 1111 - "Faith Off" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1112 - "The Mansion Family" | Spears, BritneyBritney Spears | Herself |
| 1113 - "Saddlesore Galactica" | Bachman, RandyRandy Bachman | Himself |
| 1113 - "Saddlesore Galactica" | Cummings, JimJim Cummings | Duncan |
| 1113 - "Saddlesore Galactica" | Denman, TrevorTrevor Denman | Track announcer |
| 1113 - "Saddlesore Galactica" | Turner, C.F.C.F. Turner | Himself |
| 1114 - "Alone Again, Natura-Diddily" | Colvin, ShawnShawn Colvin | Rachel Jordan |
| 1114 - "Alone Again, Natura-Diddily" | Welker, Frank Frank Welker | Parrot |
| 1115 - "Missionary: Impossible" | White, BettyBetty White | Herself |
| 1119 - "Kill the Alligator and Run" | Bader, DiedrichDiedrich Bader | Sheriff |
| 1119 - "Kill the Alligator and Run" | C., JoeJoe C. | Himself |
| 1119 - "Kill the Alligator and Run" | Evans, RobertRobert Evans | Himself |
| 1119 - "Kill the Alligator and Run" | Rock, KidKid Rock | Himself |
| 1119 - "Kill the Alligator and Run" | Rose, CharlieCharlie Rose | Himself |
| 1120 - "Last Tap Dance in Springfield" | Welker, Frank Frank Welker | Lion |
| 1121 - "It's a Mad, Mad, Mad, Mad Marge" | Posey, ParkerParker Posey | Becky |
| 1121 - "It's a Mad, Mad, Mad, Mad Marge" | Wilmore, MarcMarc Wilmore | Dr. Wilmore |
| 1122 - "Behind the Laughter" | Forbes, JimJim Forbes | Narrator |
| 1122 - "Behind the Laughter" | Nelson, WillieWillie Nelson | Himself |
| 1202 - "A Tale of Two Springfields" | Coleman, Gary Gary Coleman | Himself |
| 1202 - "A Tale of Two Springfields" | Welker, Frank Frank Welker | Badger |
| 1202 - "A Tale of Two Springfields" | The Who The Who[M] | Themselves |
| 1203 - "Insane Clown Poppy" | Barrymore, DrewDrew Barrymore | Sophie |
| 1203 - "Insane Clown Poppy" | King, StephenStephen King | Himself |
| 1203 - "Insane Clown Poppy" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1203 - "Insane Clown Poppy" | Mohr, JayJay Mohr | Christopher Walken |
| 1203 - "Insane Clown Poppy" | Tan, AmyAmy Tan | Herself |
| 1203 - "Insane Clown Poppy" | Updike, JohnJohn Updike | Himself |
| 1204 - "Lisa the Tree Hugger" | Jackson, JoshuaJoshua Jackson | Jesse Grass |
| 1205 - "Homer vs. Dignity" | Gibbons, LeezaLeeza Gibbons | Herself |
| 1206 - "The Computer Wore Menace Shoes" | McGoohan, PatrickPatrick McGoohan | Number Six |
| 1207 - "The Great Money Caper" | Norton, EdwardEdward Norton | Devon Bradley |
| 1210 - "Pokey Mom" | Keaton, MichaelMichael Keaton | Jack Crowley |
| 1210 - "Pokey Mom" | Napier, CharlesCharles Napier | Warden |
| 1210 - "Pokey Mom" | Schimmel, RobertRobert Schimmel | Convict |
| 1210 - "Pokey Mom" | Vilanch, BruceBruce Vilanch | Himself |
| 1211 - "Worst Episode Ever" | Savini, TomTom Savini | Himself |
| 1212 - "Tennis the Menace" | Agassi, AndreAndre Agassi | Himself |
| 1212 - "Tennis the Menace" | Sampras, PetePete Sampras | Himself |
| 1212 - "Tennis the Menace" | Williams, SerenaSerena Williams | Herself |
| 1212 - "Tennis the Menace" | Williams, VenusVenus Williams | Herself |
| 1213 - "Day of the Jackanapes" | Coleman, Gary Gary Coleman | Himself |
| 1213 - "Day of the Jackanapes" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 1214 - "New Kids on the Blecch" | 'N Sync 'N Sync[N] | Themselves |
| 1215 - "Hungry, Hungry Homer" | Keach, StacyStacy Keach | Howard K. Duff VIII |
| 1216 - "Bye Bye Nerdie" | Griffin, KathyKathy Griffin | Francine |
| 1216 - "Bye Bye Nerdie" | Hooks, Jan Jan Hooks | Manjula Nahasapeemapetilon |
| 1217 - "Simpson Safari" | Welker, Frank Frank Welker | Various animals |
| 1218 - "Trilogy of Error" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1218 - "Trilogy of Error" | Muniz, FrankieFrankie Muniz | Thelonius |
| 1219 - "I'm Goin' to Praiseland" | Colvin, Shawn Shawn Colvin | Rachel Jordan |
| 1221 - "Simpsons Tall Tales" | Welker, Frank FranK Welker | Various animals |
| 1301 - "Treehouse of Horror XII" | Brosnan, PiercePierce Brosnan | Ultrahouse's Pierce Brosnan voice |
| 1301 - "Treehouse of Horror XII" | Perry, MatthewMatthew Perry | Ultrahouse's Matthew Perry voice |
| 1302 - "The Parent Rap" | Kaczmarek, JaneJane Kaczmarek | Judge Constance Harm |
| 1303 - "Homer the Moe" | R.E.M. R.E.M.[O] | Themselves |
| 1304 - "A Hunka Hunka Burns in Love" | Louis-Dreyfus, JuliaJulia Louis-Dreyfus | Gloria |
| 1304 - "A Hunka Hunka Burns in Love" | Takei, George George Takei | Waiter |
| 1305 - "The Blunder Years" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1305 - "The Blunder Years" | Newman, PaulPaul Newman | Himself |
| 1305 - "The Blunder Years" | Owen, JudithJudith Owen | Herself |
| 1306 - "She of Little Faith" | Gere, RichardRichard Gere | Himself |
| 1307 - "Brawl in the Family" | Kaczmarek, Jane Jane Kaczmarek | Judge Constance Harm |
| 1307 - "Brawl in the Family" | Lindo, DelroyDelroy Lindo | Gabriel |
| 1308 - "Sweets and Sour Marge" | Stiller, BenBen Stiller | Garth Motherloving |
| 1309 - "Half-Decent Proposal" | Lovitz, Jon Jon Lovitz | Artie Ziff |
| 1311 - "The Bart Wants What It Wants" | Puck, WolfgangWolfgang Puck | Himself |
| 1311 - "The Bart Wants What It Wants" | Witherspoon, ReeseReese Witherspoon | Greta Wolfcastle |
| 1312 - "The Lastest Gun in the West" | Weaver, DennisDennis Weaver | Buck McCoy |
| 1312 - "The Lastest Gun in the West" | Welker, Frank Frank Welker | Dog |
| 1313 - "The Old Man and the Key" | Dukakis, OlympiaOlympia Dukakis | Zelda |
| 1313 - "The Old Man and the Key" | Saluga, BillBill Saluga | Ray J. Johnson |
| 1316 - "Weekend at Burnsie's" | Phish Phish[P] | Themselves |
| 1317 - "Gump Roast" | NRBQ | Sing "You'll Never Stop The Simpsons" |
| 1318 - "I Am Furious Yellow" | Lee, StanStan Lee | Himself |
| 1319 - "The Sweetest Apu" | Lipton, JamesJames Lipton | Himself |
| 1320 - "Little Girl in the Big Ten" | Pinsky, RobertRobert Pinsky | Himself |
| 1321 - "The Frying Game" | Electra, CarmenCarmen Electra | Herself |
| 1321 - "The Frying Game" | Sternhagen, FrancesFrances Sternhagen | Mrs. Bellamy |
| 1322 - "Papa's Got a Brand New Badge" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1402 - "How I Spent My Strummer Vacation" | Costello, ElvisElvis Costello | Himself |
| 1402 - "How I Spent My Strummer Vacation" | Jagger, MickMick Jagger | Himself |
| 1402 - "How I Spent My Strummer Vacation" | Kravitz, LennyLenny Kravitz | Himself |
| 1402 - "How I Spent My Strummer Vacation" | Petty, TomTom Petty | Himself |
| 1402 - "How I Spent My Strummer Vacation" | Richards, KeithKeith Richards | Himself |
| 1402 - "How I Spent My Strummer Vacation" | Setzer, BrianBrian Setzer | Himself |
| 1403 - "Bart vs. Lisa vs. the Third Grade" | Bennett, Tony Tony Bennett | Himself |
| 1404 - "Large Marge" | Baha Men Baha Men[Q] | Themselves |
| 1404 - "Large Marge" | Hooks, Jan Jan Hooks | Manjula Nahasapeemapetilon |
| 1404 - "Large Marge" | Ward, BurtBurt Ward | Robin |
| 1404 - "Large Marge" | West, Adam Adam West | Batman |
| 1405 - "Helter Shelter" | Holmes, LarryLarry Holmes | Himself |
| 1405 - "Helter Shelter" | Lander, DavidDavid Lander | Squiggy |
| 1406 - "The Great Louse Detective" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 1407 - "Special Edna" | Richard, LittleLittle Richard | Himself |
| 1408 - "The Dad Who Knew Too Little" | Gould, ElliottElliott Gould | Himself |
| 1409 - "Strong Arms of the Ma" | Reed, Pamela Pamela Reed | Ruth Powers |
| 1410 - "Pray Anything" | Leslie, LisaLisa Leslie | Herself |
| 1411 - "Barting Over" | Blink-182 Blink-182[R] | Themselves |
| 1411 - "Barting Over" | Hawk, TonyTony Hawk | Himself |
| 1411 - "Barting Over" | Kaczmarek, Jane Jane Kaczmarek | Judge Constance Harm |
| 1412 - "I'm Spelling as Fast as I Can" | Plimpton, GeorgeGeorge Plimpton | Himself |
| 1413 - "A Star Is Born Again" | Brooks, James L.James L. Brooks | Himself |
| 1413 - "A Star Is Born Again" | Fielding, HelenHelen Fielding | Herself |
| 1413 - "A Star Is Born Again" | Tomei, MarisaMarisa Tomei | Sara Sloane |
| 1414 - "Mr. Spritz Goes to Washington" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1416 - "'Scuse Me While I Miss the Sky" | Idle, EricEric Idle | Declan Desmond |
| 1416 - "'Scuse Me While I Miss the Sky" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1417 - "Three Gays of the Condo" | Thompson, ScottScott Thompson | Grady |
| 1417 - "Three Gays of the Condo" | Yankovic, "Weird Al""Weird Al" Yankovic | Himself |
| 1418 - "Dude, Where's My Ranch?" | Byrne, DavidDavid Byrne | Himself |
| 1418 - "Dude, Where's My Ranch?" | Serkis, AndyAndy Serkis | Cleanie |
| 1418 - "Dude, Where's My Ranch?" | Thomas, Jonathan TaylorJonathan Taylor Thomas | Luke Stetson |
| 1419 - "Old Yeller Belly" | Keach, Stacy Stacy Keach | Howard K. Duff VII |
| 1420 - "[[Brake My Wife, Please]" | Browne, JacksonJackson Browne | Himself |
| 1420 - "Brake My Wife, Please" | Buscemi, SteveSteve Buscemi | Himself |
| 1420 - "Brake My Wife, Please" | Kaczmarek, Jane Jane Kaczmarek | Judge Constance Harm |
| 1422 - "Moe Baby Blues" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1501 - "Treehouse of Horror XIV" | De La Hoya, OscarOscar De La Hoya | Himself |
| 1501 - "Treehouse of Horror XIV" | Garner, JenniferJennifer Garner | Herself |
| 1501 - "Treehouse of Horror XIV" | Herschbach, Dudley R.Dudley R. Herschbach | Himself |
| 1501 - "Treehouse of Horror XIV" | Lewis, JerryJerry Lewis | Professor John Frink Sr. |
| 1502 - "My Mother the Carjacker" | Close, Glenn Glenn Close | Mona Simpson |
| 1503 - "The President Wore Pearls" | Moore, MichaelMichael Moore | Himself |
| 1504 - "The Regina Monologues" | Blair, TonyTony Blair | Himself |
| 1504 - "The Regina Monologues" | Leeves, JaneJane Leeves | Edwina |
| 1504 - "The Regina Monologues" | Marriott, EvanEvan Marriott | Himself |
| 1504 - "The Regina Monologues" | McKellen, IanIan McKellen | Himself |
| 1504 - "The Regina Monologues" | Rowling, J. K.J. K. Rowling | Herself |
| 1505 - "The Fat and the Furriest" | Napier, Charles Charles Napier | Grant Conor |
| 1506 - "Today I Am a Clown" | Mason, Jackie Jackie Mason | Rabbi Hyman Krustofski |
| 1506 - "Today I An a Clown" | T, Mr.Mr. T | Himself |
| 1510 - "Diatribe of a Mad Housewife" | Clancy, TomTom Clancy | Himself |
| 1510 - "Diatribe of a Mad Housewife" | Olsen, AshleyAshley Olsen | Herself |
| 1510 - "Diatribe of a Mad Housewife" | Olsen, Mary-KateMary-Kate Olsen | Herself |
| 1510 - "Diatribe of a Mad Housewife" | Pynchon, ThomasThomas Pynchon | Himself |
| 1512 - "Milhouse Doesn't Live Here Anymore" | Bakay, NickNick Bakay | Salem Saberhagen |
| 1512 - "Milhouse Doesn't Live Here Anymore" | Daniels, William William Daniels | K.I.T.T. |
| 1512 - "Milhouse Doesn't Live Here Anymore" | Sanford, IsabelIsabel Sanford | Herself |
| 1512 - "Milhouse Doesn't Live Here Anymore" | Tufeld, Dick Dick Tufeld | Lost in Space robot |
| 1513 - "Smart and Smarter" | Cowell, SimonSimon Cowell | Henry |
| 1514 - "The Ziff Who Came to Dinner" | Lovitz, Jon Jon Lovitz | Artie Ziff
Jay Sherman
Llewelyn Sinclair
Aristotle Amadopoulis
Professor Lombardo |
| 1515 - "Co-Dependent's Day" | Brave Combo Brave Combo | Play the end credits |
| 1516 - "The Wandering Juvie" | Gellar, Sarah MichelleSarah Michelle Gellar | Gina Vendetti |
| 1516 - "The Wandering Juvie" | Kaczmarek, Jane Jane Kaczmarek | Judge Constance Harm |
| 1516 - "The Wandering Juvie" | Napier, Charles Charles Napier | Warden |
| 1517 - "My Big Fat Geek Wedding" | Groening, MattMatt Groening | Himself |
| 1519 - "Simple Simpson" | Nichols, NichelleNichelle Nichols | Herself |
| 1602 - "All's Fair in Oven War" | Caan, JamesJames Caan | Himself |
| 1602 - "All's Fair in Oven War" | Pynchon, Thomas Thomas Pynchon | Himself |
| 1604 - "She Used to Be My Girl" | Cattrall, KimKim Cattrall | Chloe Talbot |
| 1605 - "Fat Man and Little Boy" | Idle, Eric Eric Idle | Declan Desmond |
| 1608 - "Homer and Ned's Hail Mary Pass" | Brady, TomTom Brady | Himself |
| 1608 - "Homer and Ned's Hail Mary Pass" | James, LeBronLeBron James | Himself |
| 1608 - "Homer and Ned's Hail Mary Pass" | Kwan, MichelleMichelle Kwan | Herself |
| 1608 - "Homer and Ned's Hail Mary Pass" | Ming, YaoYao Ming | Himself |
| 1608 - "Homer and Ned's Hail Mary Pass" | Sapp, WarrenWarren Sapp | Himself |
| 1609 - "Pranksta Rap" | 50 Cent 50 Cent | Himself |
| 1611 - "On a Clear Day I Can't See My Sister" | Busey, GaryGary Busey | Himself |
| 1611 - "On a Clear Day I Can't See My Sister" | Kaczmarek, Jane Jane Kaczmarek | Judge Constance Harm |
| 1612 - "Goo Goo Gai Pan" | Liu, LucyLucy Liu | Madam Wu |
| 1612 - "Goo Goo Gai Pan" | Wagner, RobertRobert Wagner | Himself |
| 1614 - "The Seven-Beer Snitch" | Gehry, FrankFrank Gehry | Himself |
| 1614 - "The Seven-Beer Snitch" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1614 - "The Seven-Beer Snitch" | Napier, Charles Charles Napier | Officer Krackney |
| 1615 - "Future-Drama" | DiMaggio, JohnJohn DiMaggio | Bender |
| 1615 - "Future-Drama" | Poehler, AmyAmy Poehler | Jenda |
| 1616 - "Don't Fear the Roofer" | Hawking, Stephen Stephen Hawking | Himself |
| 1616 - "Don't Fear the Roofer" | Ramano, RayRay Ramano | Ray Magini |
| 1617 - "The Heartbroke Kid" | Brooks, Albert Albert Brooks | Tab Spangler |
| 1618 - "A Star Is Torn" | Barrino, FantasiaFantasia Barrino | Clarissa Wellington |
| 1619 - "Thank God It's Doomsday" | Baha Men | Sing "Who Wants a Haircut?" |
| 1619 - "Thank God It's Doomsday" | Los Lobos Los Lobos | Play end credits |
| 1620 - "Home Away from Homer" | Bateman, JasonJason Bateman | Himself |
| 1621 - "The Father, the Son, and the Holy Guest Star" | Neeson, LiamLiam Neeson | Father Sean |
| 1701 - "Bonfire of the Manatees" | Baldwin, Alec Alec Baldwin | Caleb Thorn |
| 1701 - "Bonfire of the Manatees" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1704 - "Treehouse of Horror XVI" | Bradshaw, TerryTerry Bradshaw | Himself |
| 1704 - "Treehouse of Horror XVI" | Rodman, DennisDennis Rodman | Himself |
| 1707 - "The Last of the Red Hat Mamas" | Tomlin, LilyLily Tomlin | Tammy |
| 1708 - "The Italian Bob" | Cucinotta, Maria GraziaMaria Grazia Cucinotta | Francessa |
| 1708 - "The Italian Bob" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 1710 - "Homer's Paternity Coot" | Frazier, Joe Joe Frazier | Himself |
| 1710 - "Homer's Paternity Coot" | Macy, William H.William H. Macy | Himself |
| 1710 - "Homer's Paternity Coot" | York, MichaelMichael York | Mason Fairbanks |
| 1713 - "The Seemingly Never-Ending Story" | LaMarche, Maurice Maurice LaMarche | Commander McBragg |
| 1714 - "Bart Has Two Mommies" | Fargas, AntonioAntonio Fargas | Huggy Bear |
| 1714 - "Bart Has Two Mommies" | Johnson, RandyRandy Johnson | Himself |
| 1714 - "Bart Has Two Mommies" | Sarandon, Susan Susan Sarandon | Herself |
| 1714 - "Bart Has Two Mommies" | Thomas, Dave Dave Thomas | Bob Hope |
| 1715 - "Homer Simpson, This Is Your Wife" | Gervais, RickyRicky Gervais | Charles |
| 1716 - "Million Dollar Abie" | Reiner, RobRob Reiner | Himself |
| 1717 - "Kiss Kiss, Bang Bangalore" | Anderson, Richard DeanRichard Dean Anderson | Himself |
| 1719 - "Girls Just Want to Have Sums" | McDormand, FrancesFrances McDormand | Melanie Upfoot |
| 1720 - "Regarding Margie" | Bando, SalSal Bando | Himself |
| 1720 - "Regarding Margie" | Tenace, GeneGene Tenace | Himself |
| 1721 - "The Monkey Suit" | Griffith, MelanieMelanie Griffith | Herself |
| 1721 - "The Monkey Suit" | Hagman, LarryLarry Hagman | Wallace Brady |
| 1722 - "Marge and Homer Turn a Couple Play" | Keach, Stacy Stacy Keach | Howard K. Duff VII |
| 1722 - "Marge and Homer Turn a Couple Play" | Moore, MandyMandy Moore | Tabitha Vixx |
| 1801 - "The Mook, the Chef, the Wife and Her Homer" | Imperioli, MichaelMichael Imperioli | Dante Calabresis Jr. |
| 1801 - "The Mook, the Chef, the Wife and Her Homer" | Mantegna, Joe Joe Mantegna | Fat Tony |
| 1801 - "The Mook, the Chef, the Wife and Her Homer" | Metallica Metallica[S] | Themselves |
| 1801 - "The Mook, the Chef, the Wife and Her Homer" | Pantoliano, JoeJoe Pantoliano | Dante Calabresis |
| 1802 - "Jazzy and the Pussycats" | The White Stripes The White Stripes[T] | Themselves |
| 1804 - "Treehouse of Horror XVII" | Drescher, FranFran Drescher | Female Golem |
| 1804 - "Treehouse of Horror XVII" | Lewis, RichardRichard Lewis | Male Golem |
| 1804 - "Treehouse of Horror XVII" | LaMarche, Maurice Maurice LaMarche | Orson Welles |
| 1804 - "Treehouse of Horror XVII" | McGraw, PhilPhil McGraw | Himself |
| 1804 - "Treehouse of Horror XVII" | Sir Mix-a-Lot Sir Mix-a-Lot | Sings "Baby Likes Fat" |
| 1805 - "G.I. (Annoyed Grunt)" | Sutherland, KieferKiefer Sutherland | Colonel |
| 1806 - "Moe'N'a Lisa" | Chabon, MichaelMichael Chabon | Himself |
| 1806 - "Moe'N'a Lisa" | Franzen, JonathanJonathan Franzen | Himself |
| 1806 - "Moe'N'a Lisa" | Simmons, J.K.J.K. Simmons | J. Jonah Jameson |
| 1805 - "Moe'N'a Lisa" | Vidal, GoreGore Vidal | Himself |
| 1805 - "Moe'N'a Lisa" | Wolfe, TomTom Wolfe | Himself |
| 1809 - "Kill Gil, Volumes I & II" | Stojko, ElvisElvis Stojko | Himself |
| 1810 - "The Wife Aquatic" | LaMarche, Maurice Maurice LaMarche | Billy |
| 1810 - "The Wife Aquatic" | Shimono, Sab Sab Shimono | Japanese fisherman |
| 1812 - "Little Big Girl" | Portman, NatalieNatalie Portman | Darcy |
| 1813 - "Springfield Up" | Idle, Eric Eric Idle | Declan Desmond |
| 1814 - "Yokel Chords" | Bogdanovich, PeterPeter Bogdanovich | Psychologist |
| 1814 - "Yokel Chords" | Dick, AndyAndy Dick | Himself |
| 1814 - "Yokel Chords" | Patterson, JamesJames Patterson | Himself |
| 1814 - "Yokel Chords" | Ryan, MegMeg Ryan | Dr. Stacy Swanson |
| 1814 - "Yokel Chords" | Sondheim, StephenStephen Sondheim | Himself |
| 1815 - "Rome-old and Juli-eh" | Kaczmarek, Jane Jane Kaczmarek | Judge Constance Harm |
| 1816 - "Homerazzi" | Lovitz, Jon Jon Lovitz | Enrico Irriazio |
| 1816 - "Homerazzi" | Simmons, J. K. J. K. Simmons | Tabloid editor |
| 1816 - "Homerazzi" | White, Betty Betty White | Herself |
| 1817 - "Marge Gamer" | Ronaldo Ronaldo | Himself |
| 1820 - "Stop or My Dog Will Shoot" | Giuliani, RudyRudy Giuliani | Himself[U] |
| 1820 - "Stop or My Dog Will Shoot" | Hawking, Stephen Stephen Hawking | Himself |
| 1820 - "Stop or My Dog Will Shoot" | LaMarche, Maurice Maurice LaMarche | Horn stuffer |
| 1821 - "24 Minutes" | Rajskub, Mary LynnMary Lynn Rajskub | Chloe O'Brian |
| 1821 - "24 Minutes" | Sutherland, Kiefer Kiefer Sutherland | Jack Bauer |
| 1822 - "You Kent Always Say What You Want" | LaMarche, Maurice Maurice LaMarche | Fox announcer |
| 1822 - "You Kent Always Say What You Want" | Ludacris Ludacris | Himself |
| 1901 - "He Loves to Fly and He D'ohs" | Colbert, StephenStephen Colbert | Colby Kraus |
| 1901 - "He Loves to Fly and He D'ohs" | Ritchie, LionelLionel Ritchie | Himself |
| 1902 - "Homer of Seville" | Domingo, PlácidoPlácido Domingo | Himself |
| 1902 - "Homer of Seville" | Rudolph, MayaMaya Rudolph | Julia |
| 1903 - "Midnight Towboy" | Dillon, MattMatt Dillon | Louie |
| 1904 - "I Don't Wanna Know Why the Caged Bird Sings" | Buscemi, Steve Steve Buscemi | Dwight David Diddlehoffer |
| 1904 - "I Don't Wanna Know Why the Caged Bird Sings" | Louis-Dreyfus, Julia Julia Louis-Dreyfus | Gloria |
| 1904 - "I Don't Wanna Know Why the Caged Bird Sings" | Nugent, TedTed Nugent | Himself |
| 1905 - "Treehouse of Horror XVIII" | LaMarche, Maurice Maurice LaMarche | Government official |
| 1907 - "Husbands and Knives" | Black, JackJack Black | Milo |
| 1907 - "Husbands and Knives" | Clowes, DanielDaniel Clowes | Himself |
| 1907 - "Husbands and Knives" | LaMarche, Maurice Maurice LaMarche | Jock |
| 1907 - "Husbands and Knives" | Moore, AlanAlan Moore | Himself |
| 1907 - "Husbands and Knives" | Spiegelman, ArtArt Spiegelman | Himself |
| 1908 - "Funeral for a Fiend" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 1908 - "Funeral for a Fiend" | Mahoney, JohnJohn Mahoney | Dr. Robert Terwilliger, Sr. |
| 1908 - "Funeral for a Fiend" | Olbermann, KeithKeith Olbermann | Himself |
| 1908 - "Funeral for a Fiend" | Pierce, David Hyde David Hyde Pierce | Cecil Terwilliger |
| 1910 - "E Pluribus Wiggum" | Rather, DanDan Rather | Himself |
| 1910 - "E Pluribus Wiggum" | Stewart, JonJon Stewart | Himself |
| 1911 - "That 90's Show" | Loder, KurtKurt Loder | Himself |
| 1911 - "That 90's Show" | Yankovic, "Weird Al" "Weird Al" Yankovic | Himself |
| 1913 - "The Debarted" | Grace, TopherTopher Grace | Donny |
| 1913 - "The Debarted" | Gross, TerryTerry Gross | Herself |
| 1916 - "Papa Don't Leech" | D'Angelo, Beverly Beverly D'Angelo | Lurleen Lumpkin |
| 1916 - "Papa Don't Leech" | Dixie Chicks Dixie Chicks[V] | Themselves |
| 1917 - "Apocalypse Cow" | Deschanel, ZooeyZooey Deschanel | Mary |
| 1918 - "Any Given Sundance" | Jarmusch, JimJim Jarmusch | Himself |
| 1918 - "Any Given Sundance" | Reilly, John C.John C. Reilly | Himself |
| 1919 - "Mona Leaves-a" | Armstrong, LanceLance Armstrong | Himself |
| 1920 - "All About Lisa" | Carey, DrewDrew Carey | Himself |
| 1919 - "Mona Leaves-a" | Close, Glenn Glenn Close | Mona Simpson |
| 2001 - "Sex, Pies and Idiot Scrapes" | Forster, RobertRobert Forster | Lucky Jim |
| 2001 - "Sex, Pies and Idiot Scrapes" | Louis-Dreyfus, Julia Julia Louis-Dreyfus | Gloria |
| 2001 - "Sex, Pies and Idiot Scrapes" | Mantegna, Joe Joe Mantegna |
| 2002 - "Lost Verizon" | Grazer, Brian Brian Grazer | Himself |
| 2002 - "Lost Verizon" | Leary, DenisDenis Leary | Himself |
| 2003 - "Double, Double, Boy in Trouble" | Montana, JoeJoe Montana | Himself |
| 2005 - "Dangerous Curves" | LaMarche, Maurice Maurice LaMarche | Toucan Sam |
| 2006 - "Homer and Lisa Exchange Cross Words" | Reagle, MerlMerl Reagle | Himself |
| 2006 - "Homer and Lisa Exchange Cross Words" | Shortz, WillWill Shortz | Himself |
| 2006 - "Homer and Lisa Exchange Cross Words" | Thompson, Scott Scott Thompson | Grady |
| 2007 - "Mypods and Boomsticks" | Aghdashloo, ShohrehShohreh Aghdashloo | Mina |
| 2008 - "The Burns and the Bees" | Albert, MarvMarv Albert | Himself |
| 2008 - "The Burns and the Bees" | Bezos, JeffJeff Bezos | Himself |
| 2008 - "The Burns and the Bees" | Cuban, MarkMark Cuban | Himself |
| 2009 - "Lisa the Drama Queen" | Blunt, EmilyEmily Blunt | Juliet |
| 2009 - "Lisa the Drama Queen" | Fall Out Boy Fall Out Boy | Play the end credits |
| 2012 - "No Loan Again, Naturally" | LaMarche, Maurice Maurice LaMarche | Robert D. Eisenhower |
| 2013 - "Gone Maggie Gone" | Begley Jr., Ed Ed Begley, Jr. | Himself |
| 2014 - "In the Name of the Grandfather" | Hansard, GlenGlen Hansard | Street musician |
| 2014 - "In the Name of the Grandfather" | Irglová, MarkétaMarkéta Irglová | Eastern European woman |
| 2014 - "In the Name of the Grandfather" | Meaney, ColmColm Meaney | Tom O'Flanagan |
| 2015 - "Wedding for Disaster" | Grammer, Kelsey Kelsey Grammer | Sideshow Bob |
| 2017 - "The Good, the Sad and the Drugly" | Hathaway, AnneAnne Hathaway | Jenny |
| 2019 - "Waverly Hills 9-0-2-1-D'oh" | LaMarche, Maurice Maurice LaMarche | Inspector |
| 2019 - "Waverly Hills 9-0-2-1-D'oh" | Page, EllenEllen Page | Alaska Nebraska |
| 2020 - "Four Great Women and a Manicure" | Foster, JodieJodie Foster | Maggie Simpson |
| 2101 - "Homer the Whopper" | Groening, Matt Matt Groening | Himself |
| 2101 - "Homer the Whopper" | Rogen, SethSeth Rogen | Lyle McCarthy |
| 2101 - "Homer the Whopper" | Richardson, Kevin MichaelKevin Michael Richardson | Security guard |
| 2103 - "The Great Wife Hope" | Liddell, ChuckChuck Liddell | Himself |
| The Simpsons Movie | Brooks, Albert Albert Brooks | Russ Cargill |
| The Simpsons Movie | Green Day Green Day[W] | Themselves |
| The Simpsons Movie | Hanks, TomTom Hanks | Himself |
| The Simpsons Movie | Mantegna, Joe Joe Mantegna | Fat Tony |
| The Simpsons Movie | Rosenthal, PhilipPhilip Rosenthal | TV Dad |
