| | Portrait | Name | Time in office | Electoral mandates | Political party | Parliaments | Ministry |
| 1st |  | Sir John A. Macdonald (1st time of 2) | 1 July 1867 5 November 1873 | 1867, 1872 | Conservative | 1st 2nd | 1st |
| Integration of Rupert's Land and the North-Western Territory into Canada; Manitoba Act; Red River Rebellion; Confederation of British Columbia; Creation of the North-West Mounted Police; Pacific Scandal. |
| 2nd |  | Alexander Mackenzie
| 7 November 1873 8 October 1878 | 1874 | Liberal | 2nd 3rd | 2nd |
| Pacific Scandal; Creation of the Supreme Court; Establishment of the Royal Military College; Created the office of the Auditor General. |
| 1st |  | Sir John A. Macdonald (2nd time of 2) | 17 October 1878 6 June 1891 | 1878, 1882, 1887, 1891 | Conservative | 4th, 5th 6th, 7th | 3rd |
| National Policy; North-West Rebellion; Hanging of Louis Riel. |
| 3rd |  | Sir John Abbott | 16 June 1891 24 November 1892 | - | Conservative | 7th | 4th |
| - |
| 4th |  | Sir John Thompson | 5 December 1892 12 December 1894 | - | Conservative | 7th | 5th |
| Manitoba Schools Question. |
| 5th |  | Sir Mackenzie Bowell | 21 December 1894 27 April 1896 | - | Conservative | 7th | 6th |
| Manitoba Schools Question. |
| 6th |  | Sir Charles Tupper | 1 May 1896 8 July 1896 | - | Conservative | - | 7th |
| Manitoba Schools Question. |
| 7th |  | Sir Wilfrid Laurier | 11 July 1896 6 October 1911 | 1896, 1900, 1904, 1908 | Liberal | 8th, 9th 10th, 11th | 8th |
| Manitoba Schools Question; Boer War; Confederation of Alberta and Saskatchewan; Creation of the Royal Canadian Navy; Reciprocity with the US. |
| 8th |  | Sir Robert Borden | 10 October 1911 10 July 1920 | 1911, 1917 | Conservative; Unionist | 12th 13th | 9th 10th |
| First World War; Military Service Act; Conscription Crisis of 1917; Unionist Party (Canada); Creation of the National Research Council; Introduction of income tax; Winnipeg General Strike; Nickle Resolution. |
| 9th |  | Arthur Meighen (1st time of 2) | 10 July 1920 29 December 1921 | - | N.L.C. | 13th | 11th |
| - |
| 10th |  | William Lyon Mackenzie King (1st time of 3) | 29 December 1921 29 June 1926 | 1921, 1925 | Liberal | 14th 15th | 12th |
| King-Byng Affair. |
| 9th |  | Arthur Meighen (2nd time of 2) | 29 June 1926 25 September 1926 | - | Conservative | 15th | 13th |
| King-Byng Affair. |
| 10th |  | William Lyon Mackenzie King (2nd time of 3) | 25 September 1926 6 August 1930 | 1926 | Liberal | 16th | 14th |
| Introduction of old age pensions; Great Depression. |
| 11th |  | Richard Bedford Bennett | 7 August 1930 23 October 1935 | 1930 | Conservative | 17th | 15th |
| Great Depression. |
| 10th |  | William Lyon Mackenzie King (3rd time of 3) | 23 October 1935 15 November 1948 | 1935, 1940, 1945 | Liberal | 18th, 19th 20th | 16th |
| Creation of the Canadian Broadcasting Corporation; National Film Board of Canada; Nationalization of the Bank of Canada; World War 2; Trans-Canada Airlines. |
| 12th | | Louis St. Laurent | 15 November 1948 21 June 1957 | 1949, 1953 | Liberal | 20th, 21st 22nd | 17th |
| Canada's entrance into NATO and the UN; Suez Crisis; Creation of the United Nations Emergency Force; London Declaration; Newfoundland Act; Equalization; Trans-Canada Highway; St. Lawrence Seaway; Trans-Canada Pipeline; Pipeline Debate. |
| 13th | | John Diefenbaker | 21 June 1957 22 April 1963 | 1957, 1958, 1962 | Progressive Conservative | 23rd, 24th 25th | 18th |
| Avro Arrow cancellation; Coyne Affair; Cuban Missile Crisis; Canadian Bill of Rights. |
| 14th | | Lester B. Pearson | 22 April 1963 20 April 1968 | 1963, 1965 | Liberal | 26th 27th | 19th |
| Bomarc missile program; Introduction of Canadian universal healthcare; Canada Pension Plan; Canada Student Loans; Creation of a new Canadian flag; Auto Pact; Rejection of troop deployment to Vietnam; Royal Commission on Bilingualism and Biculturalism; Creation of the Canadian Forces; 1967 Canadian Centennial celebrations. |
| 15th | | Pierre Trudeau (1st time of 2) | 20 April 1968 4 June 1979 | 1968, 1972, 1974 | Liberal | 27th, 28th 29th, 30th | 20th |
| "Trudeaumania"; "Just Society"; October Crisis; Use of the War Measures Act; Official Languages Act; Establishment of relations with China; Creation of Petro-Canada; Membership in the G7. |
| 16th | | Joe Clark | 4 June 1979 3 March 1980 | 1979 | Progressive Conservative | 31st | 21st |
| Youngest Canadian PM. |
| 15th | | Pierre Trudeau (2nd time of 2) | 3 March 1980 30 June 1984 | 1980 | Liberal | 32nd | 22nd |
| Introduction of the NEP; 1980 Referendum; Access to Information Act; Repatriation of the Canadian Constitution; Canadian Charter of Rights and Freedoms; Western alienation. |
| 17th |  | John Turner | 30 June 1984 17 September 1984 | - | Liberal | 32nd | 23rd |
| Trudeau Patronage Appointments |
| 18th | | Brian Mulroney | 17 September 1984 25 June 1993 | 1984, 1988 | Progressive Conservative | 33rd 34th | 24th |
| Cancellation of the NEP; Meech Lake Accord; Air India bombing; Canada-US Free Trade Agreement; Introduction of the GST; Charlottetown Accord; Good relations with Ronald Reagan; Petro-Canada privatization; Gulf War; École Polytechnique massacre; Oka Crisis; Environmental Protection Act; NAFTA; Airbus affair. |
| 19th | | Kim Campbell | 25 June 1993 4 November 1993 | - | Progressive Conservative | 34th | 25th |
| First female Prime Minister of Canada. |
| 20th |  | Jean Chrétien | 4 November 1993 12 December 2003 | 1993, 1997, 2000 | Liberal | 35th, 36th 37th | 26th |
| Red Book; HST; 1995 Referendum; Clarity Act; Assassination attempt; Kosovo War; 1997 Red River Flood; Social Union Framework Agreement; Creation of Nunavut Territory; Youth Criminal Justice Act; Shawinigan Handshake; Invasion of Afghanistan; Opposition to the Invasion of Iraq; Sponsorship scandal; Gomery Inquiry. |
| 21st |  | Paul Martin | 12 December 2003 6 February 2006 | 2004 | Liberal | 37th 38th | 27th |
| Sponsorship scandal; Gomery inquiry; Civil Marriage Act; Kelowna Accord; Rejection of US Anti-Missile Treaty; G20; Atlantic Accord. |
| 22nd | | Stephen Harper | 6 February 2006 Incumbent | 2006, 2008 | Conservative | 39th 40th | 28th |
| Federal Accountability Act; GST Reduction; Afghan Mission Extension; Chuck Cadman Affair; Québécois nation motion; Apology for Chinese Head Tax; Israel-Lebanon Conflict; Veterans' Bill of Rights; Residential Schools Apology; Financial crisis of 2007-2009; 2008 Canadian parliamentary dispute; 2009 Budget; Abousfian Abdelrazik; 2009 flu pandemic. |