A total of 46 different players have been selected first. Of those, all but 11 have been Canadian in nationality. The Montreal Canadiens have had the most first overall picks of any other team, selecting five players first between 1963 and 1980. Five players have come from the London Knights of the Ontario Hockey League, more than any other team. Eight players have won the Calder Memorial Trophy as the NHL's rookie of the year, and five have been inducted into the Hockey Hall of Fame.
| Draft | Selected by | Player | Nat. | Position | Amateur/junior/former club | League |
| 1963 | Montreal Canadiens | Monahan, GarryGarry Monahan | Canada Canada | Forward | St. Michael's Juveniles | — |
| 1964 | Detroit Red Wings | Gauthier, ClaudeClaude Gauthier ¤ | Canada Canada | Forward | Comite des jeunes (Rosemont) | — |
| 1965 | New York Rangers | Veilleux, AndreAndre Veilleux ¤ | Canada Canada | Forward | Montreal Jr. B | — |
| 1966 | Boston Bruins | Gibbs, BarryBarry Gibbs | Canada Canada | Defenceman | Estevan Bruins | SJHL |
| 1967 | Los Angeles Kings | Pagnutti, RickRick Pagnutti ¤ | Canada Canada | Defenceman | Garson Native Sons | NOHA |
| 1968 | Montreal Canadiens | Plasse, MichelMichel Plasse | Canada Canada | Goaltender | Drummondville Rangers | QMJHL |
| 1969 | Montreal Canadiens | Houle, RejeanRejean Houle | Canada Canada | Forward | Montreal Junior Canadiens | OHA |
| 1970 | Buffalo Sabres | Perreault, GilbertGilbert Perreault # | Canada Canada | Forward | Montreal Junior Canadiens | OHA |
| 1971 | Montreal Canadiens | Lafleur, GuyGuy Lafleur * | Canada Canada | Forward | Quebec Remparts | QMJHL |
| 1972 | New York Islanders | Harris, BillyBilly Harris | Canada Canada | Forward | Peterborough Petes | OHA |
| 1973 | New York Islanders | Potvin, DenisDenis Potvin # | Canada Canada | Defenceman | Ottawa 67's | OHA |
| 1974 | Washington Capitals | Joly, GregGreg Joly | Canada Canada | Defenceman | Regina Pats | WCHL |
| 1975 | Philadelphia Flyers | Bridgman, MelMel Bridgman | Canada Canada | Forward | Victoria Cougars | WCHL |
| 1976 | Washington Capitals | Green, RickRick Green | Canada Canada | Defenceman | London Knights | OHA |
| 1977 | Detroit Red Wings | McCourt, DaleDale McCourt | Canada Canada | Forward | Hamilton Fincups | OHA |
| 1978 | Minnesota North Stars | Smith, BobbyBobby Smith ^ | Canada Canada | Forward | Ottawa 67's | OHA |
| 1979 | Colorado Rockies | Ramage, RobRob Ramage | Canada Canada | Defenceman | London Knights | OHA |
| 1980 | Montreal Canadiens | Wickenheiser, DougDoug Wickenheiser | Canada Canada | Forward | Regina Pats | WHL |
| 1981 | Winnipeg Jets | Hawerchuk, DaleDale Hawerchuk # | Canada Canada | Forward | Cornwall Royals | QMJHL |
| 1982 | Boston Bruins | Kluzak, GordGord Kluzak | Canada Canada | Defenceman | Billings Bighorns | WHL |
| 1983 | Minnesota North Stars | Lawton, BrianBrian Lawton | United States USA | Forward | Mount Saint Charles Academy | — |
| 1984 | Pittsburgh Penguins | Lemieux, MarioMario Lemieux # | Canada Canada | Forward | Laval Voisins | QMJHL |
| 1985 | Toronto Maple Leafs | Clark, WendelWendel Clark | Canada Canada | Forward | Saskatoon Blades | WHL |
| 1986 | Detroit Red Wings | Murphy, JoeJoe Murphy | Canada Canada | Forward | Michigan State | CCHA |
| 1987 | Buffalo Sabres | Turgeon, PierrePierre Turgeon | Canada Canada | Forward | Granby Bisons | QMJHL |
| 1988 | Minnesota North Stars | Modano, MikeMike Modano | United States USA | Forward | Prince Albert Raiders | WHL |
| 1989 | Quebec Nordiques | Sundin, MatsMats Sundin | Sweden Sweden | Forward | Nacka HK | Sweden |
| 1990 | Quebec Nordiques | Nolan, OwenOwen Nolan | Canada Canada | Forward | Cornwall Royals | OHL |
| 1991 | Quebec Nordiques | Lindros, EricEric Lindros | Canada Canada | Forward | Oshawa Generals | OHL |
| 1992 | Tampa Bay Lightning | Hamrlik, RomanRoman Hamrlik | Czech Republic TCH | Defenceman | HC Zlin | Czechoslovakia |
| 1993 | Ottawa Senators | Daigle, AlexandreAlexandre Daigle | Canada Canada | Forward | Victoriaville Tigres | QMJHL |
| 1994 | Florida Panthers | Jovanovski, EdEd Jovanovski | Canada Canada | Defenceman | Windsor Spitfires | OHL |
| 1995 | Ottawa Senators | Berard, BryanBryan Berard ^ | United States USA | Defenceman | Detroit Junior Red Wings | OHL |
| 1996 | Ottawa Senators | Phillips, ChrisChris Phillips | Canada Canada | Defenceman | Prince Albert Raiders | WHL |
| 1997 | Boston Bruins | Thornton, JoeJoe Thornton | Canada Canada | Forward | Sault Ste. Marie Greyhounds | OHL |
| 1998 | Tampa Bay Lightning | Lecavalier, VincentVincent Lecavalier | Canada Canada | Forward | Rimouski Océanic | QMJHL |
| 1999 | Atlanta Thrashers | Stefan, PatrikPatrik Stefan | Czech Republic Czech Republic | Forward | Long Beach Ice Dogs | IHL |
| 2000 | New York Islanders | DiPietro, RickRick DiPietro | United States USA | Goaltender | Boston University | Hockey East |
| 2001 | Atlanta Thrashers | Kovalchuk, IlyaIlya Kovalchuk | Russia Russia | Forward | Spartak Moscow | Russia |
| 2002 | Columbus Blue Jackets | Nash, RickRick Nash | Canada Canada | Forward | London Knights | OHL |
| 2003 | Pittsburgh Penguins | Fleury, Marc-AndreMarc-Andre Fleury | Canada Canada | Goaltender | Cape Breton Screaming Eagles | QMJHL |
| 2004 | Washington Capitals | Ovechkin, AlexanderAlexander Ovechkin ^ | Russia Russia | Forward | Dynamo Moscow | Russia |
| 2005 | Pittsburgh Penguins | Crosby, SidneySidney Crosby | Canada Canada | Forward | Rimouski Océanic | QMJHL |
| 2006 | St. Louis Blues | Johnson, ErikErik Johnson | United States USA | Defenceman | United States NTDP | — |
| 2007 | Chicago Blackhawks | Kane, PatrickPatrick Kane ^ | United States USA | Forward | London Knights | OHL |
| 2008 | Tampa Bay Lightning | Stamkos, StevenSteven Stamkos | Canada Canada | Forward | Sarnia Sting | OHL |
| 2009 | New York Islanders | Tavares, JohnJohn Tavares | Canada Canada | Forward | London Knights | OHL |