The Leser-Trélat sign is the explosive onset of multiple seborrheic keratoses (many pigmented skin lesions),^[1]:638[2] often with an inflammatory base. This can be an ominous sign of internal malignancy as part of a paraneoplastic syndrome. In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic.

It is named for Edmund Leser and Ulysse Trélat.^[3]

Although most associated neoplasms are gastrointestinal adenocarcinomas (stomach, liver, colorectal and pancreas), breast, lung, and urinary tract cancers, as well as lymphoid malignancies are associated with this impressive rash. It is likely that various cytokines and other growth factors produced by the neoplasm are responsible for the abrupt appearance of the seborrheic keratoses. In some cases, paraneoplastic acanthosis nigricans accompanies the sign of Leser-Trélat.

[edit] Citations

1. ^ Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Clinical diagnosis by laboratory methods; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
2. ^ "eMedicine - Sign of Leser-Trelat : Article by Robert A Schwartz". http://www.emedicine.com/DERM/topic915.htm. 
3. ^ synd/3211 at Who Named It?

[edit] References

• Heaphy MR, Millns JL, Schroeter AL (August 2000). "The sign of Leser-Trélat in a case of adenocarcinoma of the lung". J. Am. Acad. Dermatol. 43 (2 Pt 2): 386–90. PMID 10901731. http://linkinghub.elsevier.com/retrieve/pii/a104967. 

• Kurzrock R, Cohen PR (December 1995). "Cutaneous paraneoplastic syndromes in solid tumors". Am. J. Med. 99 (6): 662–71. PMID 7503090. http://linkinghub.elsevier.com/retrieve/pii/S000293439980254X. 

• Schwartz RA (July 1996). "Sign of Leser-Trélat". J. Am. Acad. Dermatol. 35 (1): 88–95. doi:10.1016/S0190-9622(96)90502-2. PMID 8682971. http://linkinghub.elsevier.com/retrieve/pii/S0190-9622(96)90502-2. 

• Gregory B, Ho VC (February 1992). "Cutaneous manifestations of gastrointestinal disorders. Part I". J. Am. Acad. Dermatol. 26 (2 Pt 1): 153–66. PMID 1552046. 

• Kilickap S, Yalcin B (May 2007). "Images in clinical medicine. The sign of Leser-Trélat". N. Engl. J. Med. 356 (21): 2184. doi:10.1056/NEJMicm062851. PMID 17522402. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=17522402&promo=ONFLNS19. 

• Yaniv R, Servadio Y, Feinstein A, Trau H (March 1994). "The sign of Leser-Trélat associated with transitional cell carcinoma of the urinary-bladder--a case report and short review". Clin. Exp. Dermatol. 19 (2): 142–5. PMID 8050144. 

• New Zealand Dermatological Society Includes images

v • d • e Eponymous medical signs for integumentary system Skin Asboe-Hansen sign - Auspitz's sign - Crowe sign - Darier's sign - Koebner's phenomenon - Leser-Trelat sign - Florid cutaneous papillomatosis - Nikolsky's sign - Wickham striae Nails Aldrich-Mees' lines - Beau's lines - Muehrcke's lines - Terry's nails integument, SF, LCT navs: anat/physio, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc skin appendage navs: anat, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc

v • d • e Eponymous medical signs for oncology Hematological malignancy Russell bodies · Auer rod · Bence Jones protein Nodes Virchow's node · Sister Mary Joseph nodule · Lund's node Other Call-Exner bodies · Leser-Trélat sign · Trousseau sign of malignancy · Courvoisier's law

v • d • e Paraneoplastic syndromes Endocrine Hypercalcaemia · SIADH · Zollinger-Ellison syndrome  · Cushing's syndrome Hematological Granulocytosis Neurological Paraneoplastic cerebellar degeneration  · Encephalomyelitis · Limbic encephalitis · Opsoclonus · Polymyositis · Transverse myelitis · Lambert-Eaton myasthenic syndrome Mucocutaneous Dermatomyositis  · Leser-Trélat sign · Acanthosis nigricans · Florid cutaneous papillomatosis · Necrolytic migratory erythema · Sweet's syndrome · Pyoderma gangrenosum

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