lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Identifiers
Symbol	LSS
Entrez	4047
HUGO	6708
OMIM	600909
RefSeq	NM_002340
UniProt	P48449
Other data
EC number	5.4.99.7
Locus	Chr. 21 q22.3

Lanosterol synthase is an enzyme that converts 2,3-oxidosqualene to a protosterol cation and finally to lanosterol.

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• MeSH Lanosterol+synthase

This biochemistry article is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Isomerase: mutases (EC 5.4) 5.4.2 Phosphomutases Phosphoglycerate mutase · Bisphosphoglycerate mutase · Phosphoglucomutase 5.4.99 Other groups Methylmalonyl-CoA mutase · Lanosterol synthase

v • d • e Metabolism: lipid metabolism · ketones/cholesterol synthesis enzymes/steroid metabolism Mevalonate pathway To HMG-CoA Acetyl-Coenzyme A acetyltransferase · HMG-CoA synthase (regulated step) Ketogenesis HMG-CoA lyase · 3-hydroxybutyrate dehydrogenase · Thiophorase To Mevalonic acid HMG-CoA reductase To DMAPP Mevalonate kinase · Phosphomevalonate kinase · Pyrophosphomevalonate decarboxylase · Isopentenyl-diphosphate delta isomerase Geranyl- Dimethylallyltranstransferase · Geranyl pyrophosphate To cholesterol To lanosterol Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase 7-Dehydrocholesterol path Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase Desmosterol path 24-dehydrocholesterol reductase To Bile acids Cholesterol 7α-hydroxylase · Sterol 27-hydroxylase Steroidogenesis To pregnenolone Side-chain cleavage To corticosteroids aldosterone: 18-hydroxylase cortisol/cortisone: 17α-hydroxylase · 11β dehydrogenase (HSD11B1, HSD11B2) both: 3β dehydrogenase · 21α-hydroxylase · 11β-hydroxylase To sex hormones To androgens 17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase (1,2) To estrogens Aromatase Other/ungrouped Steroid sulfatase · Steroidogenic acute regulatory protein see also intermediates, disorders