LRRTM1
Identifiers
Symbol	LRRTM1
Entrez	347730
HUGO	19408
OMIM	610867
RefSeq	NM_178839
Other data
Locus	Chr. 2 p12

LRRTM1^[1], or Leucine-rich repeat transmembrane neuronal protein 1, is the first gene linked to increased odds of being left-handed^[2][3][4]. The researchers also found evidence that possessing one particular variant of this gene slightly raises the risk of psychotic mental illnesses such as schizophrenia^[5]. As the name implies, its protein product is a transmembrane protein, which contains many leucine rich repeats, that is present in neurons. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).

The original research article from 2007 was published in the journal Molecular Psychiatry: http://www.nature.com/mp/journal/v12/n12/abs/4002053a.html. The researchers who discovered LRRTM1's potential involvement in left-handedness and schizophrenia also released a statement for the press and public in July 2007.

[edit] See also

• Handedness

[edit] References

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