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The Kuma–Manych Depression (Russian: Кумо–Манычская впадина, Kumo–Manychskaya vpadina), is a geological depression in southwestern Russia that separates the Russian Plain (north) from the Fore-Caucasus (south). It is named after Kuma and Manych rivers.

It is often regarded as the natural boundary between Europe and Asia. (It was once officially declared as the boundary by Peter II of Russia in 1730 after the geographical works by Philip Johan von Strahlenberg.)

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