Kaempferol
IUPAC name	3,5,7-trihydroxy-2- (4-hydroxyphenyl)-4H-1- benzopyran-4-one
Other names	Kaempherol; Robigenin; Pelargidenolon; Rhamnolutein; Rhamnolutin; Populnetin; Trifolitin; Kempferol; Swartziol
Identifiers
CAS number	520-18-3 Y
PubChem	5280863
Properties
Molecular formula	C15H10O6
Molar mass	286.23 g/mol
Exact mass	286.047738
Melting point	276-278 °C
Y (what is this?)  (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Kaempferol is a natural flavonoid that has been isolated from tea,^[1] broccoli, Delphinium, Witch-hazel, grapefruit, brussel sprouts, apples and other plant sources. Kaempferol is a yellow crystalline solid with a melting point of 276-278 °C. It is slightly soluble in water but soluble in hot ethanol and diethyl ether.

Many glycosides of kaempferol, such as kaempferitrin and astragalin, have been isolated as natural products from plants. Kaempferol consumption in tea and broccoli has been associated with reduced risk of heart disease.^{[citation needed]}

Kaempferol is what gives the flowers of Acacia decurrens and Acacia longifolia their color.^[2] The compound has antidepressant properties.^{[3][unreliable source?]}

An 8-year study found that three flavonols (kaempferol, quercetin, and myricetin) reduced the risk of pancreatic cancer by 23 percent.^[4]

UCLA cancer researchers have found that study participants who ate foods containing certain flavonoids seemed to be protected from developing lung cancer. Dr. Zuo-Feng Zhang, of the UCLA's Jonsson Cancer Center and a professor of public health and epidemiology at the UCLA School of Public Health said the flavonoids that appeared to be the most protective included catechin, found in strawberries and green and black teas; kaempferol, found in brussel sprouts and apples; and quercetin, found in beans, onions and apples.^[5]

[edit] Metabolism

The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl methionine and kaempferol to produce S-adenosylhomocysteine and kaempferide.

[edit] Glycosides

• Astragalin (Astragaline, asragalin, kaempferol-3-O-glucoside)
• Sophoraflavonoloside (kaempferol 3-O-sophoroside)
• Kaempferol-3-O-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside, a known bitter-tasting flavonoid glycoside, can be isolated from the rhizomes of Selliguea feei^[6].

[edit] List of the plants that contains the chemical

• Kaempferia galanga^{[citation needed]}

[edit] Toxicology

This section requires expansion.

[edit] References

• [Kaempferol treatment increased the expression and the mitochondria localization of the NAD-dependent deacetylase SIRT3. The chronic myelogenous leukemiae K562 cells stably overexpressing SIRT3 were more sensitive to kaempferol, whereas SIRT3 silencing did not increase the resistance of K562 cells to kaempferol ( Marfe G et al 2009).]

[edit] External links

• Flavonoid composition of tea: Comparison of black and green teas

-mitochondrial effect.