KHDRBS1 Information & KHDRBS1 Links at HealthHaven.com

KH domain containing, RNA binding, signal transduction associated 1
Identifiers
Symbols	KHDRBS1; p62; FLJ34027; Sam68
External IDs	OMIM: 602489 MGI: 893579 HomoloGene: 4781
Gene ontology
Molecular function	• DNA binding; • RNA binding; • SH3/SH2 adaptor activity; • protein binding; • transcription repressor activity;
Cellular component	• nucleus; • membrane;
Biological process	• G2/M transition of mitotic cell cycle; • transcription; • regulation of transcription, DNA-dependent; • mRNA processing; • cell cycle; • cell cycle arrest; • cell surface receptor linked signal transduction; • cell proliferation; • negative regulation of transcription; • regulation of RNA export from nucleus;
RNA expression pattern
	More reference expression data
Orthologs
NP_006550 (protein)	NP_035447 (protein)

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KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene.^[1]^[2]

[edit] References

^ Wong G, Muller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F (Jun 1992). "Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62". Cell 69 (3): 551-8. PMID 1374686.
^ Lee J, Burr JG (Jan 2000). "Salpalpha and Salpbeta, growth-arresting homologs of Sam68". Gene 240 (1): 133-47. PMID 10564820.

[edit] Further reading

Najib S, Martín-Romero C, González-Yanes C, Sánchez-Margalet V (2005). "Role of Sam68 as an adaptor protein in signal transduction.". Cell. Mol. Life Sci. 62 (1): 36–43. doi:10.1007/s00018-004-4309-3. PMID 15619005.
Koch CA, Moran MF, Anderson D, et al. (1992). "Multiple SH2-mediated interactions in v-src-transformed cells.". Mol. Cell. Biol. 12 (3): 1366–74. PMID 1545818.
Weng Z, Thomas SM, Rickles RJ, et al. (1994). "Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.". Mol. Cell. Biol. 14 (7): 4509–21. PMID 7516469.
Taylor SJ, Anafi M, Pawson T, Shalloway D (1995). "Functional interaction between c-Src and its mitotic target, Sam 68.". J. Biol. Chem. 270 (17): 10120–4. doi:10.1074/jbc.270.17.10120. PMID 7537265.
Richard S, Yu D, Blumer KJ, et al. (1995). "Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.". Mol. Cell. Biol. 15 (1): 186–97. PMID 7799925.
Nunès JA, Truneh A, Olive D, Cantrell DA (1996). "Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules.". J. Biol. Chem. 271 (3): 1591–8. doi:10.1074/jbc.271.3.1591. PMID 8576157.
Vadlamudi RK, Joung I, Strominger JL, Shin J (1996). "p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.". J. Biol. Chem. 271 (34): 20235–7. doi:10.1074/jbc.271.34.20235. PMID 8702753.
Finan PM, Hall A, Kellie S (1996). "Sam68 from an immortalised B-cell line associates with a subset of SH3 domains.". FEBS Lett. 389 (2): 141–4. doi:10.1016/0014-5793(96)00552-2. PMID 8766817.
Bunnell SC, Henry PA, Kolluri R, et al. (1996). "Identification of Itk/Tsk Src homology 3 domain ligands.". J. Biol. Chem. 271 (41): 25646–56. doi:10.1074/jbc.271.41.25646. PMID 8810341.
Andreotti AH, Bunnell SC, Feng S, et al. (1997). "Regulatory intramolecular association in a tyrosine kinase of the Tec family.". Nature 385 (6611): 93–7. doi:10.1038/385093a0. PMID 8985255.
Trüb T, Frantz JD, Miyazaki M, et al. (1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.". J. Biol. Chem. 272 (2): 894–902. doi:10.1074/jbc.272.2.894. PMID 8995379.
Lawe DC, Hahn C, Wong AJ (1997). "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68.". Oncogene 14 (2): 223–31. doi:10.1038/sj.onc.1200821. PMID 9010224.
Barlat I, Maurier F, Duchesne M, et al. (1997). "A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain.". J. Biol. Chem. 272 (6): 3129–32. doi:10.1074/jbc.272.6.3129. PMID 9013542.
Fusaki N, Iwamatsu A, Iwashima M, Fujisawa J (1997). "Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.". J. Biol. Chem. 272 (10): 6214–9. doi:10.1074/jbc.272.10.6214. PMID 9045636.
Guinamard R, Fougereau M, Seckinger P (1997). "The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS.". Scand. J. Immunol. 45 (6): 587–95. doi:10.1046/j.1365-3083.1997.d01-447.x. PMID 9201297.
Resnick RJ, Taylor SJ, Lin Q, Shalloway D (1997). "Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis.". Oncogene 15 (11): 1247–53. doi:10.1038/sj.onc.1201289. PMID 9315091.
Chen T, Damaj BB, Herrera C, et al. (1997). "Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain.". Mol. Cell. Biol. 17 (10): 5707–18. PMID 9315629.
Tang J, Feng GS, Li W (1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor.". Oncogene 15 (15): 1823–32. doi:10.1038/sj.onc.1201351. PMID 9362449.
Sung CK, Choi WS, Sanchez-Margalet V (1998). "Guanosine triphosphatase-activating protein-associated protein, but not src-associated protein p68 in mitosis, is a part of insulin signaling complexes.". Endocrinology 139 (5): 2392–8. doi:10.1210/en.139.5.2392. PMID 9564850.

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[pmid1374686-0] Wong G, Muller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F (Jun 1992). "Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62". Cell 69 (3): 551-8. PMID 1374686.

[pmid10564820-1] Lee J, Burr JG (Jan 2000). "Salpalpha and Salpbeta, growth-arresting homologs of Sam68". Gene 240 (1): 133-47. PMID 10564820.

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