Joseph O'Brien may refer to:

• Joseph J. O'Brien (1897-1953), former U.S. congressman from New York
• Joseph Leonard O'Brien, (1895-1973), former Lieutenant Governor of New Brunswick
• Joey O'Brien, Irish international and Bolton Wanderers footballer
• Joe O'Brien, basketball player

This disambiguation page lists articles associated with the same personal name. If an internal link led you here, you may wish to change the link to point directly to the intended article.