John O'Connor may refer to:
- John Joseph O'Connor (1920–2000), Cardinal and eleventh bishop of the Archdiocese of New York
- Father John O'Connor (1870–1952), British priest
- John J. O'Connor (1885–1960), former US Representative from New York
- John O'Connor (coach), American college football coach
- John Joseph O'Connor (Bishop of Newark) (1855–1927), Fourth bishop of the Diocese of Newark
- John O'Connor (Canadian politician) (1824–1887), Canadian politician
- John O'Connor Power (c. 1846–1919), Irish politician
- John O'Connor (MP, KC) (1850–1928), Irish politician
- John O'Connor (Lord Mayor of Dublin) (c.1835–1891), Lord Mayor of Dublin and MP for South Kerry
- John O'Connor (painter) (1830–1889), Irish painter
- John O'Conor (born 1947), Irish pianist
- Johnny O'Connor (born 1980), Irish rugby union player
- John O'Connor (Irish politician) (1896–1967), Irish Fianna Fáil politician
- John O'Connor (English cricketer) (1867-1936), cricketer
- Jack O'Connor (Australian cricketer), four time Test cricketer for Australia
- John O'Connor (DJ/Producer) (1980), DJ/producer
- John O'Connor (musician), TV composer and recording artist from London
- John J. O'Connor (journalist) (1933-2009), American journalist and critic
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