Issa or ISSA may refer to: - Issa
- Darrell Issa, a Californian Representative
- Deities in The Belgariad#Issa, a divine character in David Eddings's fantasy series The Belgariad and The Malloreon
- Issa or Isa, the Arabic name for Jesus in Islam
- Issa, an ancient Greek colony on the Adriatic island of Vis
- Issa, another name for the Catawba tribe of Native Americans
- Issa, Japanese haiku poet - full name Kobayashi Issa
- Issa, the nickname of Luttif Afif, the leader of the Black September terror squad at the 1972 Olympic Games
- Issa-Aimé Nthépé, French sprinter
- Issa Al Murbati
- Issa al Qaida guest house, Faisalabad
- Issa (Senegalese singer) (born Issa Diop), singer, songwriter, and record producer
- Issa Hassan, Kurdish musician and singer living in France
- Issa Hentona, lead singer of J-pop band Da Pump
- Issa Sesay, a military leader in the Sierra Leone insurgency
- Issa (clan), Somali clan that resides in Djibouti
- Issa (clothing), London fashion company, participant in Fall 2008 fashion weeks, known for its artistic prints
- Issa (singer), the identity which Canadian musician Jane Siberry took upon changing her name
- Issa (urban-type settlement), an urban-type settlement in Penza Oblast, Russia
- ISSA
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